Okada Maki, Nakao Ryuji, Momosaki Sotaro, Yanamoto Kazuhiko, Kikuchi Tatsuya, Okamura Toshimitsu, Wakizaka Hidekatsu, Hosoi Rie, Zhang Ming-Rong, Inoue Osamu
Molecular Imaging Centre, National Institute of Radiological Sciences, 4-9-1 Anagawa, Chiba 263-8555, Japan.
Appl Radiat Isot. 2013 Aug;78:102-7. doi: 10.1016/j.apradiso.2013.04.025. Epub 2013 Apr 25.
Brain uptake of acetate is insufficient for obtaining a quantitative image of astrocytic oxidative metabolism. To improve the brain uptake of [1-(11)C]acetate, we synthesized benzyl [1-(11)C]acetate ([1-(11)C]BA) and conducted a positron emission tomography (PET) study assessing astrocytic oxidative metabolism. The brain uptake of [1-(11)C]BA was markedly higher compared with [1-(11)C]acetate, and disappeared with a half-life of 20 min in all regions studied. The brain uptake of [1-(11)C]BA was significantly decreased by fluorocitrate. The results indicate that [1-(11)C]BA could be a useful PET probe for assessing astrocytic oxidative metabolism.
大脑对乙酸盐的摄取不足以获得星形胶质细胞氧化代谢的定量图像。为了提高[1-(11)C]乙酸盐的脑摄取量，我们合成了苄基[1-(11)C]乙酸盐([1-(11)C]BA)，并进行了一项正电子发射断层扫描(PET)研究，以评估星形胶质细胞的氧化代谢。与[1-(11)C]乙酸盐相比，[1-(11)C]BA的脑摄取量显著更高，并且在所有研究区域中以20分钟的半衰期消失。氟代柠檬酸显著降低了[1-(11)C]BA的脑摄取量。结果表明，[1-(11)C]BA可能是一种用于评估星形胶质细胞氧化代谢的有用PET探针。
