Baker G T, Sprott R L
American Association for Advances in Health Care Research, Silver Spring, Maryland 20904.
Exp Gerontol. 1988;23(4-5):223-39. doi: 10.1016/0531-5565(88)90025-3.
This article presents a conceptual discussion of some aspects involved in biomarkers of aging. A biomarker of aging is a biological parameter of an organism that either alone or in some multivariate composite will, in the absence of disease, better predict functional capability at some late age than will chronological age. The reasons for undertaking biomarker research, criteria for putative biomarkers, measurement and assessment of putative biomarkers, and the new initiative by the National Institute on Aging in biomarker research are discussed.
本文对衰老生物标志物所涉及的一些方面进行了概念性讨论。衰老生物标志物是生物体的一个生物学参数，在无疾病的情况下，该参数单独或与某些多变量组合相比，比实际年龄能更好地预测晚年的功能能力。文中讨论了开展生物标志物研究的原因、假定生物标志物的标准、假定生物标志物的测量与评估，以及美国国立衰老研究所生物标志物研究的新倡议。
