快速抗抑郁作用：进展顺利。
Rapid antidepressant effects: moving right along.
机构信息
Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.
出版信息
Mol Psychiatry. 2013 Aug;18(8):856-63. doi: 10.1038/mp.2013.55. Epub 2013 May 21.
Abstract
Available treatments for depression have significant limitations, including low response rates and substantial lag times for response. Reports of rapid antidepressant effects of a number of compounds, including the glutamate N-methyl-D-aspartate receptor antagonist ketamine, have spurred renewed translational neuroscience efforts aimed at elucidating the molecular and cellular mechanisms of action that result in rapid therapeutic response. This perspective provides an overview of recent advances utilizing compounds with rapid-acting antidepressant effects, discusses potential mechanism of action and provides a framework for future research directions aimed at developing safe, efficacious antidepressants that achieve satisfactory remission not only by working rapidly but also by providing a sustained response.
摘要
目前的抗抑郁治疗方法存在明显的局限性，包括应答率低和应答时间长。一些化合物，包括谷氨酸 N-甲基-D-天冬氨酸受体拮抗剂氯胺酮，具有快速抗抑郁作用的报告，激发了重新开展转化神经科学研究的努力，旨在阐明导致快速治疗反应的分子和细胞作用机制。本文概述了利用具有快速抗抑郁作用的化合物的最新进展，讨论了潜在的作用机制，并为未来的研究方向提供了框架，旨在开发安全有效的抗抑郁药，不仅通过快速起效，而且通过提供持续的反应来实现满意的缓解。
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