Jiang Haoyu, Quan Shoubo, Su Yahai, Li Jingyi, Zhang Xuefeng
Haoyu Jiang, Department of Anesthesiology, The Affiliated Dongguan Songshan Lake Central Hospital, Guangdong Medical University, Dongguan 441000, Guangdong, China.
Shoubo Quan, Department of Anesthesiology, SSL Central Hospital of Dongguan City, Affiliated Shilong People's Hospital of Southern Medical University, Dongguan 523326, Guangdong, China.
Pak J Med Sci. 2024 Oct;40(9):1914-1918. doi: 10.12669/pjms.40.9.8689.
To evaluate the clinical effects of Esketamine combining Sufentanil in labor analgesia and their impacts on postpartum depression.
This was a retrospective study. One hundred and fifty primiparae with spontaneous labor were selected at SSL Central Hospital of Dongguan City from July 10, 2021 to May 10, 2022 as the research objects and randomly divided into two groups (each n=75). While the control group underwent epidural infusion of Sufentanil for analgesia, the study group was administered Esketamine combining Sufentanil. Compared analgesic effects, time of birth course, adverse reactions, pain intensity, scores assigned to depression and anxiety before analgesia and after delivery were made for pregnant women in both groups.
The response rates of the study and control groups reached 100% and 93%, respectively, with statistically significant differences (p=0.02). The time of the first, second, and third stages of labor in the study group were all significantly lower than that of the control group; showing statistical significance (p=0.00). Regarding adverse reactions showed no statistically significant differences (p=0.44). Moreover, the study group showed noticeably lower pain intensity than those of the control group during delivery, 20 minutes and one hour after delivery; and their differences were statistically significant (p=0.00). After delivery, both the SAS and SDS of the study group were respectively lower than those of the control group, with statistically significant differences as well (p=0.00).
Applying Esketamine combining Sufentanil in epidural painless delivery produces rather favorable analgesic effects, shortens the time of the birth process, and improves postpartum anxiety and depression without leading to more adverse reactions.
评估艾司氯胺酮联合舒芬太尼用于分娩镇痛的临床效果及其对产后抑郁的影响。
本研究为回顾性研究。选取2021年7月10日至2022年5月10日在东莞市松山湖中心医院自然分娩的150例初产妇作为研究对象，随机分为两组（每组n = 75）。对照组采用硬膜外输注舒芬太尼进行镇痛，研究组给予艾司氯胺酮联合舒芬太尼。比较两组孕妇的镇痛效果、产程时间、不良反应、疼痛强度、镇痛前及产后抑郁和焦虑评分。
研究组和对照组的有效率分别达到100%和93%，差异有统计学意义（p = 0.02）。研究组第一产程、第二产程和第三产程的时间均显著低于对照组，差异有统计学意义（p = 0.00）。不良反应方面差异无统计学意义（p = 0.44）。此外，研究组在分娩时、分娩后20分钟和1小时的疼痛强度明显低于对照组，差异有统计学意义（p = 0.00）。产后，研究组的SAS和SDS评分分别低于对照组，差异也有统计学意义（p = 0.00）。
艾司氯胺酮联合舒芬太尼用于硬膜外无痛分娩镇痛效果良好，可缩短产程时间，改善产后焦虑和抑郁，且不会导致更多不良反应。
