静脉注射米卡芬净在炎症人眼中的眼内穿透。
Intraocular penetration of intravenous micafungin in inflamed human eyes.
机构信息
Department of Ophthalmology, Gifu University Graduate School of Medicine, Gifu, Japan.
出版信息
Antimicrob Agents Chemother. 2013 Aug;57(8):4027-30. doi: 10.1128/AAC.02300-12. Epub 2013 May 20.
Abstract
Eight eyes of 7 patients with fungal disease received intravenous injections of 150 to 300 mg micafungin, and samples of blood, cornea, retina-choroid, aqueous humor, and vitreous humor were collected. The micafungin levels in all collected samples exceeded the MICs; however, the levels in the vitreous and aqueous humors were lower. Our findings suggest that intravenous micafungin should be given in combination with intravitreal antifungal agents after vitrectomy in severe cases of intraocular fungal diseases.
摘要
7 例真菌病患者的 8 只眼接受了 150 至 300mg 米卡芬净的静脉注射，采集了血液、角膜、视网膜脉络膜、房水和玻璃体样本。所有采集样本中的米卡芬净浓度均超过 MIC，但玻璃体和房水中的浓度较低。我们的研究结果表明，对于严重眼内真菌病患者，玻璃体切除术后应联合静脉注射和玻璃体内抗真菌药物。
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