Filgueiras-Rama David, Arias Miguel A, Iniesta Angel, Armada Eduardo, Merino José L, Peinado Rafael, López-Sendón J L
Cardiac Electrophysiology Unit, Department of Cardiology, Hospital Universitario La Paz, Paseo de la Castellana 261, 1st floor, 28046 Madrid, Spain ; Robotic Cardiac Electrophysiology and Arrhythmia Unit, Hospital Universitario La Paz, Madrid, Spain.
Pulm Med. 2013;2013:426758. doi: 10.1155/2013/426758. Epub 2013 Apr 3.
Obstructive sleep apnea (OSA) is a common disorder characterized by repetitive interruption of ventilation during sleep caused by recurrent upper airway collapse, which leads to intermittent hypoxia. The disorder is commonly undiagnosed despite its relationship with substantial cardiovascular morbidity and mortality. Moreover, the effects of the disorder appear to be particularly dangerous in young subjects. In the last decade, substantial clinical evidence has identified OSA as independent risk factor for both bradyarrhythmias and tachyarrhythmias. To date the mechanisms leading to such arrhythmias have not been completely understood. However, recent data from animal models and new molecular analyses have increased our knowledge of the field, which might lead to future improvement in current therapeutic strategies mainly based on continuous positive airway pressure. This paper aims at providing readers a brief and specific revision of current knowledge about the mechanisms underlying atrial arrhythmias in OSA and their clinical and therapeutic implications.
阻塞性睡眠呼吸暂停（OSA）是一种常见疾病，其特征是睡眠期间反复出现上气道塌陷导致通气反复中断，进而引起间歇性缺氧。尽管该疾病与严重的心血管发病率和死亡率相关，但通常未被诊断出来。此外，该疾病在年轻受试者中的影响似乎尤为危险。在过去十年中，大量临床证据已将OSA确定为缓慢性心律失常和快速性心律失常的独立危险因素。迄今为止，导致此类心律失常的机制尚未完全明确。然而，来自动物模型的最新数据和新的分子分析增加了我们在该领域的认识，这可能会使目前主要基于持续气道正压通气的治疗策略在未来得到改进。本文旨在为读者简要且具体地综述关于OSA中心房心律失常潜在机制及其临床和治疗意义的当前知识。
