Bandi Pushyami Satya, Panigrahy Preetish Kumar, Hajeebu Sreehita, Ngembus Ngonack J, Heindl Stacey E
Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Pharmacology, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Cureus. 2021 Jul 1;13(7):e16086. doi: 10.7759/cureus.16086. eCollection 2021 Jul.
Sleep-disordered breathing (SDB) comprising obstructive sleep apnea (OSA) is found in more than half of patients with heart failure (HF) and may have negative impacts on cardiovascular function. Increased atherosclerotic cardiovascular disease and the development of coronary events and congestive heart failure are associated with OSA. It is associated with a substandard quality of life, increased hospitalizations, and a poor prognosis. Despite its association with severe cardiovascular morbidity and mortality, the condition is frequently underdiagnosed. The substantial clinical evidence has established OSA as an independent risk factor for bradyarrhythmias and tachyarrhythmias in the last decade. The mechanisms which lead to such arrhythmias are uncertain. In short, OSA patients have a significantly elevated risk of HF and atrial fibrillation (AF). The direct correlation between HF, SDB, and cardiac arrhythmias has been poorly understood. The purpose of this study is to get a better understanding of the relation between AF, OSA, and HF by focusing on the pathophysiological mechanisms underlying these conditions. Therefore, we searched for articles to support our association in PubMed and Google Scholar databases.
在超过半数的心力衰竭(HF)患者中发现了包括阻塞性睡眠呼吸暂停(OSA)在内的睡眠呼吸紊乱(SDB),其可能对心血管功能产生负面影响。动脉粥样硬化性心血管疾病的增加以及冠状动脉事件和充血性心力衰竭的发展与OSA相关。它与生活质量不合格、住院次数增加以及预后不良有关。尽管其与严重的心血管发病率和死亡率相关,但该病症常常未被充分诊断。在过去十年中,大量临床证据已将OSA确立为缓慢性心律失常和快速性心律失常的独立危险因素。导致此类心律失常的机制尚不确定。简而言之,OSA患者发生HF和心房颤动(AF)的风险显著升高。HF、SDB和心律失常之间的直接关联一直未得到充分理解。本研究的目的是通过关注这些病症背后的病理生理机制,更好地理解AF、OSA和HF之间的关系。因此,我们在PubMed和谷歌学术数据库中搜索文章以支持我们的关联。