IgG4 相关唾液腺炎罕见：129 例慢性下颌下唾液腺炎的组织病理学研究。
IgG4-related sialadenitis is rare: histopathological investigation of 129 cases of chronic submandibular sialadenitis.
机构信息
Unit of Oral Pathology, King's College London Dental Institute at Guy's, King's College, St Thomas' Hospitals, London, UK.
出版信息
Histopathology. 2013 Jul;63(1):96-102. doi: 10.1111/his.12122. Epub 2013 May 20.
AIMS
The incidence of IgG4-related sialadenitis among cases of chronic sialadenitis is unknown, and so we investigated the presence of IgG4 plasma cells in 129 specimens from an archival collection of consecutive cases of chronic submandibular sialadenitis collected from 1969 to 1989 that had been previously extensively characterized.
METHODS AND RESULTS
Immunohistology revealed that only three of the 129 specimens contained areas over the threshold for IgG4-related sialadenitis of 50 IgG4 plasma cells per high-power field, and these cells were part of a non-specific chronic inflammatory infiltrate associated with ducts that had contained sialoliths. The infiltrate of IgG4 plasma cells in the series was significantly positively related to the total infiltrate of inflammatory cells, fibrosis, atrophy, lymphoid germinal centres and sialoliths.
CONCLUSIONS
IgG4-related sialadenitis is rare and was not found in the present series. The IgG4 plasma cells that were present in the glands were part of a non-specific chronic inflammatory infiltrate.
目的
IgG4 相关涎腺炎在慢性涎腺炎病例中的发病率尚不清楚，因此我们调查了 1969 年至 1989 年间连续收集的 129 份慢性下颌下腺炎存档标本中 IgG4 浆细胞的存在情况，这些标本先前已经过广泛特征描述。
方法和结果
免疫组织化学显示，在 129 份标本中，只有 3 份标本中 IgG4 浆细胞的数量超过 IgG4 相关涎腺炎的阈值（每高倍视野 50 个 IgG4 浆细胞），这些细胞是与含有涎石的导管相关的非特异性慢性炎症浸润的一部分。该系列中 IgG4 浆细胞的浸润与炎症细胞、纤维化、萎缩、淋巴滤泡生发中心和涎石的总浸润呈显著正相关。
结论
IgG4 相关涎腺炎很少见，本研究系列中未发现 IgG4 相关涎腺炎。存在于腺体中的 IgG4 浆细胞是一种非特异性慢性炎症浸润的一部分。
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