Institute for the Application of Nuclear Energy, University of Belgrade, Serbia.
Free Radic Res. 2013 Aug;47 Suppl 1:28-38. doi: 10.3109/10715762.2013.806798.
Advanced glycation end-products (AGEs) are a heterogeneous group of compounds formed by the Maillard chemical process of non- enzymatic glycation of free amino groups of proteins, lipids and nucleic acids. This chemical modification of biomolecules is triggered by endogeneous hyperglycaemic or oxidative stress-related processes. Additionally, AGEs can derive from exogenous, mostly diet-related, sources. Considering that AGE accumulation in tissues correlates with ageing and is a hallmark in several age-related diseases it is not surprising that the role of AGEs in ageing and pathology has become increasingly evident. The receptor for AGEs (RAGE) is a single transmembrane protein being expressed in a wide variety of human cells. RAGE binds a broad repertoire of extracellular ligands and mediates responses to stress conditions by activating multiple signal transduction pathways being mostly responsible for acute and/or chronic inflammation. RAGE activation has been implicated in ageing as well as in a number of age-related diseases, including atherosclerosis, neurodegeneration, arthritis, stoke, diabetes and cancer. Here we present a synopsis of findings that relate to AGEs-reported implication in cell signalling pathways and ageing, as well as in pathology. Potential implications and opportunities for translational research and the development of new therapies are also discussed.
糖基化终产物（AGEs）是一组由非酶糖基化自由氨基基团的蛋白质、脂质和核酸的美拉德化学过程形成的化合物。这种生物分子的化学修饰是由内源性高血糖或氧化应激相关过程引发的。此外，AGEs 也可以来源于外源性的、主要与饮食相关的来源。考虑到组织中 AGE 的积累与衰老有关，并且是几种与年龄相关的疾病的标志，AGEs 在衰老和病理学中的作用变得越来越明显也就不足为奇了。AGEs 的受体（RAGE）是一种单一的跨膜蛋白，在多种人类细胞中表达。RAGE 结合广泛的细胞外配体，并通过激活多种信号转导途径来介导对应激条件的反应，这些途径主要负责急性和/或慢性炎症。RAGE 的激活与衰老以及许多与年龄相关的疾病有关，包括动脉粥样硬化、神经退行性变、关节炎、中风、糖尿病和癌症。在这里，我们总结了与 AGEs 相关的研究结果，这些结果涉及细胞信号通路和衰老以及病理学。还讨论了潜在的影响和转化研究以及新疗法开发的机会。
