Chen Shasha, Wang Honglun, Hu Na
Qinghai Provincial Key Laboratory of Tibetan Medicine Research and CAS Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Xining 810008, China.
School of Food and Biological Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China.
Foods. 2022 Oct 26;11(21):3377. doi: 10.3390/foods11213377.
In recent years, the relationship between Murr. anthocyanins (LRA) and health has attracted increasing attention. The purpose of this study is to investigate the anti-aging effect and mechanism of LRA through a D-galactose (DG)-induced aging rat model. Our results showed that the long-term intake of LRA, for 8 weeks, improved motor function, reduced serum aging markers, promoted the endogenous antioxidant system, and suppressed the serum inflammatory cytokines in aging rats. Besides, the LRA treatment alleviated DG-induced liver injuries by relieving the inflammation and inhibiting Fas/FasL-mediated cell death. More importantly, the abnormal serum metabolome profiles of the aging rats were restored by the LRA, relating to 38 metabolites and 44 pathways. Specifically, the LRA significantly affected the amino acid and protein-related metabolic pathways by regulating the levels of L-threonine, L-aspartic acid, glycine, L-histidine, D-homocysteine, L-homocitrulline, L-homoserine, guanidineacetic acid, and kynurenine. These results have important implications for the development of LRA as an anti-aging and liver-protective ingredient.
近年来,穆尔氏花青素(LRA)与健康之间的关系受到越来越多的关注。本研究旨在通过D-半乳糖(DG)诱导的衰老大鼠模型探讨LRA的抗衰老作用及其机制。我们的结果表明,衰老大鼠长期摄入LRA达8周,可改善运动功能,降低血清衰老标志物水平,促进内源性抗氧化系统,抑制血清炎性细胞因子。此外,LRA治疗通过减轻炎症和抑制Fas/FasL介导的细胞死亡,缓解了DG诱导的肝损伤。更重要的是,LRA恢复了衰老大鼠异常的血清代谢组谱,涉及38种代谢物和44条代谢途径。具体而言,LRA通过调节L-苏氨酸、L-天冬氨酸、甘氨酸、L-组氨酸、D-同型半胱氨酸、L-高瓜氨酸、L-高丝氨酸、胍乙酸和犬尿氨酸的水平,显著影响氨基酸和蛋白质相关的代谢途径。这些结果对于将LRA开发为抗衰老和肝脏保护成分具有重要意义。