Department of Chemistry University of Basel St Johanns Ring 19, 4056 Basel, Switzerland.
Chemphyschem. 2000 Dec 15;1(4):195-8. doi: 10.1002/1439-7641(20001215)1:4<195::AID-CPHC195>3.0.CO;2-B.
Long distance charge transport through DNA occurs by a hopping mechanism. If the positive charge is injected into a guanine base, all guanines act as charge carriers. Because of the strong influence that the distance has on the charge-transfer step, DNA strands with long adenine:thymine sequences also involve adenine as charge carriers. A prerequsite for this mechanism is that the electron transfer to an adjacent adenine base is faster than the H2 O trapping reaction of the guanine radical cation. We have developed a model that can explain and qualitatively predict the product yields.
长距离通过 DNA 的电荷传输是通过跳跃机制发生的。如果正电荷注入鸟嘌呤碱基，则所有的鸟嘌呤都充当电荷载体。由于距离对电荷转移步骤的强烈影响，具有长腺嘌呤：胸腺嘧啶序列的 DNA 链也涉及腺嘌呤作为电荷载体。这种机制的前提是电子转移到相邻的腺嘌呤碱基比鸟嘌呤自由基阳离子的 H2O 捕获反应更快。我们已经开发了一个可以解释和定性预测产物产率的模型。
