人格特质与瘦素。
Personality traits and leptin.
机构信息
Florida State University College of Medicine, 1115 W. Call Street, Tallahassee, FL 32306, USA.
出版信息
Psychosom Med. 2013 Jun;75(5):505-9. doi: 10.1097/PSY.0b013e3182919ff4. Epub 2013 May 22.
OBJECTIVE
Personality traits related to high neuroticism and low conscientiousness are consistently associated with obesity. Hormones implicated in appetite and metabolism, such as leptin, may also be related to personality and may contribute to the association between these traits and obesity. The present research examined the association between leptin and Five Factor Model personality traits.
METHODS
A total of 5214 participants (58% women; mean [standard deviation] age = 44.42 [15.93] years; range, 18-94 years) from the SardiNIA project completed the Revised NEO Personality Inventory, a comprehensive measure of personality traits, and their blood samples were assayed for leptin.
RESULTS
As expected, lower conscientiousness was associated with higher circulating levels of leptin (r = -0.05, p < .001), even after controlling for body mass index, waist circumference, or inflammatory markers (r = -0.05, p < .001). Neuroticism, in contrast, was unrelated to leptin (r = 0.01, p = .31).
CONCLUSIONS
Individuals who are impulsive and lack discipline (low conscientiousness) may develop leptin resistance, which could be one factor that contributes to obesity, whereas the relation between a proneness to anxiety and depression (high neuroticism) and obesity may be mediated through other physiological and/or behavioral pathways.
目的
与高神经质和低尽责性相关的人格特质与肥胖症密切相关。与食欲和新陈代谢有关的激素，如瘦素，也可能与人格有关，并且可能导致这些特质与肥胖之间的关联。本研究探讨了瘦素与五因素人格模型特质之间的关系。
方法
共有 5214 名参与者（58%为女性；平均[标准差]年龄=44.42[15.93]岁；年龄范围为 18-94 岁）来自 SardiNIA 项目，完成了修订版 NEO 人格量表，这是人格特质的综合衡量标准，并且对他们的血液样本进行了瘦素检测。
结果
正如预期的那样，尽责性较低与循环中更高水平的瘦素相关（r=-0.05，p<0.001），即使在控制体重指数、腰围或炎症标志物后也是如此（r=-0.05，p<0.001）。相比之下，神经质与瘦素无关（r=0.01，p=0.31）。
结论
冲动和缺乏纪律性的个体（低尽责性）可能会出现瘦素抵抗，这可能是导致肥胖的一个因素，而焦虑和抑郁倾向（高神经质）与肥胖之间的关系可能通过其他生理和/或行为途径来介导。
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