Sista Federico, Schietroma Mario, Carlei Francesco, Cecilia Emanuela Marina, Piccione Federica, De Santis Giuseppe, Lancione Laura, Iannucci Daniela, Giuliani Antonio, Amicucci Gianfranco, Leardi Sergio
Ann Ital Chir. 2013 Mar-Apr;84(2):153-8.
This study want to examine (a) whether neutrophils, the neutrophil-elastase, C-reactive protein and the Interleukin- 6 are modified and how, in patients after laparoscopic cholecystectomy open cholecystectomy; (b) whether these findings are indicative of an increased risk to develop infectious complications.
Circulating Interleukin-6 level, C-reactive protein and neutrophil-elastase were measured in 71 patients (35 underwent open cholecystectomy and 36 laparoscopic cholecystectomy). The diagnosis was confirmed by ultrasound examination. During hospitalization the patients were not given antispastic drugs, steroids, or nonsteroidal antiinflammatory drugs (NSAID).
The increase in the serum Interleukin-6 and neurtophil-elastase, during laparoscopic cholecystectomy, was found to be significantly smaller than that during open cholecystectomy and resulted in a smaller extent of postoperative elevations for C-reactive protein. We recorded three cases (8.5%) of postoperative infections in the "open'" group and neutrophil- elastase values normalized later in patient with complications.
There were significant associations between the response areas of Interleukin-6, C-reactive protein and neutrophil- elastase levels. Neutrophils-elastase level is a more sensible inflammatory marker in comparison to the IL-6 and C-reactive protein. Excessive and prolonged post injury elevations of these mediators are associated with increased morbidity.
