Ueo H, Honda M, Adachi M, Inoue H, Nakashima H, Arinaga S, Akiyoshi T
Department of Surgery, Medical Institute of Bioregulation, Kyushu University, Beppu, Japan.
Am J Surg. 1994 Oct;168(4):358-60. doi: 10.1016/s0002-9610(05)80166-7.
The chronologic changes in the serum levels of interleukin-6 (IL-6), a mediator for acute-phase inflammation, were compared between laparoscopic cholecystectomy (LC) and open cholecystectomy (OC), since these two types of operations were considered to be a unique model for examining the role of local tissue injury in postoperative inflammatory reactions. The increase in the serum IL-6 level during LC was found to be significantly smaller than that during OC and resulted in a smaller extent of postoperative elevations for C-reactive protein. These results suggest that laparoscopic surgery associated with minimal tissue injury can help limit an increase in the serum IL-6 level during surgery, thus contributing to a reduction in surgical stress.
由于认为腹腔镜胆囊切除术（LC）和开腹胆囊切除术（OC）这两种手术是研究局部组织损伤在术后炎症反应中作用的独特模型，因此比较了急性期炎症介质白细胞介素-6（IL-6）血清水平的时间变化。结果发现，LC期间血清IL-6水平的升高明显小于OC期间，且术后C反应蛋白的升高幅度也较小。这些结果表明，与最小组织损伤相关的腹腔镜手术有助于限制手术期间血清IL-6水平的升高，从而有助于减轻手术应激。
