Elfving P, Cigudosa J C, Lundgren R, Limon J, Mandahl N, Kristoffersson U, Heim S, Mitelman F
Department of Urology, University Hospital, Lund, Sweden.
Cytogenet Cell Genet. 1990;53(2-3):123-5. doi: 10.1159/000132910.
Numerical chromosome aberrations are common in several types of malignant tumors. Recently, trisomy 7 and loss of the Y chromosome were described in cultures from nonneoplastic tissue, making the significance of these aberrations as cancer-associated changes doubtful. We herein report the mosaic occurrence of trisomy 7 in four consecutive short-term cultures initiated from normal kidney tissue. Smaller clones with trisomy 10 were present in three cases, and the only culture established from a male also showed mosaic loss of the Y chromosome.
染色体数目异常在几种恶性肿瘤中很常见。最近，在非肿瘤组织培养物中发现了7号染色体三体和Y染色体缺失，这使得这些异常作为癌症相关变化的意义存疑。我们在此报告，从正常肾组织开始的连续4次短期培养物中出现了7号染色体三体的嵌合体现象。3例中存在10号染色体三体的较小克隆，且从一名男性建立的唯一培养物也显示出Y染色体的嵌合性缺失。
