Aly M S, Dal Cin P, Van de Voorde W, van Poppel H, Ameye F, Baert L, Van den Berghe H
Centre for Human Genetics, University of Leuven, Belgium.
Genes Chromosomes Cancer. 1994 Apr;9(4):227-33. doi: 10.1002/gcc.2870090402.
We combined conventional cytogenetic analysis and fluorescence in situ hybridization of short-term cultures of 28 samples from benign prostatic hyperplasia. Loss of the Y chromosome was the most common chromosome change, followed by trisomy 7. Trisomy 7, however, may be unrelated to the origin of benign prostate hyperplasia, in which the only and not very specific change seems to be the loss of the Y chromosome.
我们对28例良性前列腺增生样本的短期培养物进行了常规细胞遗传学分析和荧光原位杂交。Y染色体缺失是最常见的染色体变化，其次是7号染色体三体。然而，7号染色体三体可能与良性前列腺增生的起源无关，在良性前列腺增生中，唯一且不太特异的变化似乎是Y染色体缺失。
