发育与疾病中的转录延伸检查点控制。
Transcriptional elongation checkpoint control in development and disease.
机构信息
Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA.
出版信息
Genes Dev. 2013 May 15;27(10):1079-88. doi: 10.1101/gad.215137.113.
Abstract
Transcriptional elongation control by RNA polymerase II and its associated factors has taken center stage as a process essential for the regulation of gene expression throughout development. In this review, we analyze recent findings on the identification of factors functioning in the regulation of the transcriptional elongation checkpoint control (TECC) stage of gene expression and how the factors' misregulation is associated with disease pathogenesis, including cancer.
摘要
RNA 聚合酶 II 及其相关因子的转录延伸控制已成为调节整个发育过程中基因表达的必要过程的核心。在这篇综述中，我们分析了最近关于鉴定在基因表达的转录延伸检查点控制 (TECC) 阶段起作用的因子的发现，以及这些因子的失调如何与疾病发病机制（包括癌症）相关。
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