Ovanesov K B
Farmakol Toksikol. 1990 Mar-Apr;53(2):15-7.
After acute (10 mg/kg) and chronic (1 mg/kg, 10 days) administration melatonin facilitated parameters of rats relearning in the Y-maze. A simultaneous shortening of latency avoidance reaction was observed. Haloperidol (0.1 mg/kg) against the background of chronic melatonin administration more strongly optimized the animals' relearning. The hormonal action is supposed to depend on its sedative properties.
急性(10毫克/千克)和慢性(1毫克/千克,持续10天)给予褪黑素后,可促进大鼠在Y迷宫中重新学习的参数。同时观察到回避反应潜伏期缩短。在慢性给予褪黑素的背景下,氟哌啶醇(0.1毫克/千克)更有力地优化了动物的重新学习。推测这种激素作用取决于其镇静特性。