Dai Wei, Tan Xuexin, Sun Changfu, Zhou Qing
Department of Oromaxillofacial-Head and Neck Surgery & Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, Shenyang 110002, China.
Int J Mol Sci. 2014 May 13;15(5):8393-406. doi: 10.3390/ijms15058393.
Sex determining region Y-BOX2 (SOX2), one of the key members of the SOX family, is a transcription factor that is involved in the maintenance of embryonic stem cell pluripotency and in multiple developmental processes. Recent studies have shown that SOX2 is aberrantly expressed in several types of tumors. The present study aimed to investigate the clinicopathological and prognostic significance of SOX2 in adenoid cystic carcinoma (ACC) of salivary gland. In this study, the expression of SOX2 in ACC tissues and matched adjacent non-cancerous tissues was measured by immunohistochemistry, western blot, and quantitative polymerase chain reaction. High SOX2 expression occurred in approximately 62.6% of primary ACC. In addition, high expression of SOX2 was significantly associated with T classification (p=0.003) and distant metastasis (p=0.002). The 5-year overall survival (OS) and disease-free survival (DFS) in patients with high SOX2 expression is poorer than those with low SOX2 expression. When adjusted by multivariate analysis, high SOX2 expression, together with distant metastasis, was an independent prognostic factor. The findings of the present study provide evidence that SOX2 represents a potential novel prognostic biomarker for ACC patients.
性别决定区Y框蛋白2（SOX2）是SOX家族的关键成员之一，是一种转录因子，参与维持胚胎干细胞多能性以及多个发育过程。最近的研究表明，SOX2在几种类型的肿瘤中异常表达。本研究旨在探讨SOX2在涎腺腺样囊性癌（ACC）中的临床病理及预后意义。在本研究中，采用免疫组织化学、蛋白质印迹法和定量聚合酶链反应检测SOX2在ACC组织及配对的癌旁非癌组织中的表达。约62.6%的原发性ACC中出现SOX2高表达。此外，SOX2高表达与T分级（p=0.003）和远处转移（p=0.002）显著相关。SOX2高表达患者的5年总生存率（OS）和无病生存率（DFS）低于SOX2低表达患者。经多因素分析校正后，SOX2高表达与远处转移共同构成独立的预后因素。本研究结果提供了证据，表明SOX2是ACC患者潜在的新型预后生物标志物。
