Dănulescu Raluca, Costin D
University of Medicine and Pharmacy Grigore T Popa Iasi, Faculty of Medicine.
Rev Med Chir Soc Med Nat Iasi. 2012 Oct-Dec;116(4):1136-42.
Age related macular degeneration (AMD) is the most frequent cause of irreversible blindness in the elderly population, affecting approximately 30-50 million people around the world.
to establish the role of oxidative stress in retinal structural lesions.
It is a case-control study that included 19 patients diagnosed with AMD. Depending on the severity of the diagnosis, patients were divided into 3 groups: group 1 - mild AMD, group 2 - moderate, atrophic AMD, group 3 - severe, neovascular AMD. They were followed by assessment of visual acuity, optical coherence tomography (OCT) and oxidative stress markers like superoxide-dismutase (SOD), thiobarbituric acid reactive substances (TBARS) and inflammatory marker - C-reactive protein (CRP).
Risk factors involved in patients with AMD are arterial hypertension, smoking, hyperlipidemia and diet poor in antioxidants, as revealed in the questionnaire. Retinal thickness assessed by optical coherence tomography showed that values in patients with severity level 2 is within normal limits, while in patients with severity level 3, these values are significantly increased due to macular edema. The mean values of SOD, TBARS and CRP in the studied group were significantly higher compared to controls, being higher in group severity level 3.
This study shows the role of oxidative stress and inflammation in retinal structural lesions in AMD and the importance of blood markers in early detection of oxidative stress and thus of retinal lesions in this disease.
年龄相关性黄斑变性（AMD）是老年人群不可逆失明的最常见原因，全球约有3000万至5000万人受其影响。
确定氧化应激在视网膜结构损伤中的作用。
这是一项病例对照研究，纳入了19例诊断为AMD的患者。根据诊断的严重程度，患者被分为3组：第1组——轻度AMD，第2组——中度萎缩性AMD，第3组——重度新生血管性AMD。对他们进行了视力评估、光学相干断层扫描（OCT）以及氧化应激标志物如超氧化物歧化酶（SOD）、硫代巴比妥酸反应性物质（TBARS）和炎症标志物——C反应蛋白（CRP）的检测。
问卷显示，AMD患者的危险因素包括动脉高血压、吸烟、高脂血症和抗氧化剂含量低的饮食。光学相干断层扫描评估的视网膜厚度显示，严重程度为2级的患者的值在正常范围内，而严重程度为3级的患者，由于黄斑水肿，这些值显著增加。研究组中SOD、TBARS和CRP的平均值与对照组相比显著更高，在严重程度为3级的组中更高。
本研究表明氧化应激和炎症在AMD视网膜结构损伤中的作用，以及血液标志物在早期检测氧化应激从而检测该疾病视网膜损伤方面的重要性。
