源自精氨酸支原体的精氨酸脱亚氨酶的鉴定与纯化。
Identification and purification of arginine deiminase that originated from Mycoplasma arginini.
作者信息
Sugimura K, Fukuda S, Wada Y, Taniai M, Suzuki M, Kimura T, Ohno T, Yamamoto K, Azuma I
机构信息
Institute of Immunological Science, Hokkaido University, Sapporo, Japan.
出版信息
Infect Immun. 1990 Aug;58(8):2510-5. doi: 10.1128/iai.58.8.2510-2515.1990.
Abstract
A lymphocyte blastogenesis inhibitory factor, (LBIF), was purified from the culture supernatant of human histiocytic lymphoma U937 by fast protein liquid chromatography. In this study, we demonstrated, first, that LBIF originated from a mycoplasma, Mycoplasma arginini, infecting U937 cells, and second, that LBIF bore the arginine deiminase activity. The implication of in vivo immunosuppression induced by arginine-utilizing mycoplasma species is discussed.
摘要
一种淋巴细胞增殖抑制因子（LBIF）通过快速蛋白质液相色谱法从人组织细胞淋巴瘤U937的培养上清液中纯化得到。在本研究中，我们首先证明LBIF源自感染U937细胞的支原体——精氨酸支原体，其次证明LBIF具有精氨酸脱亚氨酶活性。本文还讨论了利用精氨酸的支原体物种在体内诱导免疫抑制的意义。
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