Nomura Ryohei, Fujii Hiroaki, Abe Masaaki, Sugo Hiroyuki, Ishizaki Yoichi, Kawasaki Seiji, Hino Okio
1 Department of Hepatobiliary-Pancreatic Surgery and.
Int Surg. 2013 Apr-Jun;98(2):164-9. doi: 10.9738/INTSURG-D-13-00001.1.
Although mesothelin is highly expressed in epithelial mesotheliomas, and also in adenocarcinomas of the ovary and pancreas, the clinical significance of mesothelin in cholangiocellular carcinoma (CC) has not been reported, and its biologic features are largely unknown. In the present study, mesothelin expression was evaluated in 25 patients with CC using a well-characterized mesothelin monoclonal antibody (5B2). A total of 8 of the 25 patients with CC (32%) showed mesothelin immunoreactivity. The 25 patients were divided into 2 groups according to the percentage of tumor cells that were positive for mesothelin expression: negative (n = 17) or focally positive (mesothelin expression evident in less than 50%, n = 4; total, n = 21 for both groups), and positive (mesothelin expression evident in 50% or more, n = 4). The survival periods in both groups were statistically analyzed. The negative/focally positive group showed significantly longer postoperative survival than the positive group (P = 0.006). Also, mesothelin positivity was identified as an independent predictor of short postoperative survival. The present results suggest that mesothelin expression is a prognostic indicator in patients with CC.
尽管间皮素在上皮性间皮瘤中高表达，在卵巢癌和胰腺癌中也有表达，但间皮素在胆管细胞癌（CC）中的临床意义尚未见报道，其生物学特性也大多未知。在本研究中，使用一种特性明确的间皮素单克隆抗体（5B2）对25例CC患者的间皮素表达进行了评估。25例CC患者中共有8例（32%）表现出间皮素免疫反应性。根据间皮素表达阳性的肿瘤细胞百分比，将25例患者分为两组：阴性组（n = 17）或局灶阳性组（间皮素表达在50%以下明显，n = 4；两组共n = 21），以及阳性组（间皮素表达在50%或以上明显，n = 4）。对两组的生存期进行了统计学分析。阴性/局灶阳性组术后生存期明显长于阳性组（P = 0.006）。此外，间皮素阳性被确定为术后生存期短的独立预测因素。目前的结果表明，间皮素表达是CC患者的一个预后指标。
