创伤弧菌的溶细胞素基因：序列及其与霍乱弧菌E1 Tor溶血素基因的关系。
The cytolysin gene of Vibrio vulnificus: sequence and relationship to the Vibrio cholerae E1 Tor hemolysin gene.
作者信息
Yamamoto K, Wright A C, Kaper J B, Morris J G
机构信息
Institute for Microbial Diseases, Osaka University, Japan.
出版信息
Infect Immun. 1990 Aug;58(8):2706-9. doi: 10.1128/iai.58.8.2706-2709.1990.
Abstract
A cytolysin of ca. 56 kilodaltons has been suggested as a possible virulence factor in Vibrio vulnificus infections. We sequenced the DNA encoding cytolytic activity and found that the sequence contained two open reading frames, vvhA and vvhB. vvhA encoded the structural gene for the cytolysin and contained the N-terminal amino acid sequence previously reported for the protein. Regions of the vvhA gene showed homology to the structural gene for the Vibrio cholerae E1 Tor hemolysin.
摘要
一种约56千道尔顿的溶细胞素被认为可能是创伤弧菌感染中的一种毒力因子。我们对编码溶细胞活性的DNA进行了测序，发现该序列包含两个开放阅读框，即vvhA和vvhB。vvhA编码溶细胞素的结构基因，并包含先前报道的该蛋白质的N端氨基酸序列。vvhA基因的区域与霍乱弧菌E1 Tor溶血素的结构基因显示出同源性。
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