Karabulut Murat, Sherk Vanessa D, Bemben Debra A, Bemben Michael G
Department of Health and Human Performance, University of Texas at Brownsville, Brownsville, TX 78520, USA.
Clin Physiol Funct Imaging. 2013 Sep;33(5):393-9. doi: 10.1111/cpf.12044. Epub 2013 Apr 23.
The goal of this study was to examine anabolic hormone, muscle damage marker and inflammation marker responses to two types of resistance training protocols in older men. Thirty-six healthy older males (mean age = 56.6 ± 0.6 years) completed 6 weeks of high-intensity resistance training (HI-RT), low-intensity resistance training with vascular restriction (LI-BFR) or no exercise control group (CON) three times per week. Three upper body exercises were performed by both exercise groups at the same intensity (at 80% 1-RM), but lower body exercises were performed by the HI-RT group at 80% 1-RM and by the LI-BFR group at 20% 1-RM with vascular restriction. Resting serum creatine kinase (CK), interleukin 6 (IL-6), insulin-like growth factor-I (IGF-I), IGF binding protein 3 (IGFBP-3) and testosterone (T) were measured before and after training. No significant group differences in resting CK, IL-6, IGF-I, IGFBP-3 and T were detected following training (P>0.05). In addition, there were no significant changes in muscle cross-sectional area (CSA), but a trend for significant decreases in the percent changes in thigh subcutaneous fat (P = 0.051). Although training-induced anabolic hormone response did not reach statistical significance, our findings on CK and IL-6 indicated that the LI-BFR training protocol was safe and well tolerated for older men to perform to improve muscular strength.
本研究的目的是检测老年男性对两种抗阻训练方案的合成代谢激素、肌肉损伤标志物和炎症标志物反应。36名健康老年男性（平均年龄 = 56.6 ± 0.6岁）每周进行3次，共完成6周的高强度抗阻训练（HI-RT）、低强度血管限制抗阻训练（LI-BFR）或无运动对照组（CON）。两个运动组均以相同强度（80% 1-RM）进行三项上肢运动，但HI-RT组以80% 1-RM进行下肢运动，LI-BFR组在血管限制下以20% 1-RM进行下肢运动。在训练前后测量静息血清肌酸激酶（CK）、白细胞介素6（IL-6）、胰岛素样生长因子-I（IGF-I）、IGF结合蛋白3（IGFBP-3）和睾酮（T）。训练后，静息CK、IL-6、IGF-I、IGFBP-3和T在组间未检测到显著差异（P>0.05）。此外，肌肉横截面积（CSA）无显著变化，但大腿皮下脂肪百分比变化有显著下降趋势（P = 0.051）。尽管训练诱导的合成代谢激素反应未达到统计学显著性，但我们关于CK和IL-6的研究结果表明，LI-BFR训练方案对老年男性提高肌肉力量而言是安全且耐受性良好的。
