Laswati Hening, Sugiarto David, Poerwandari Dewi, Pangkahila Jahja Alex, Kimura Hiroaki
Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Universitas Airlangga/ Dr. Soetomo Hospital, Surabaya, Indonesia.
Department of Andrology and Sexology, Faculty of Medicine, Universitas Udayana, Bali, Indonesia.
Chin J Physiol. 2018 Jun;61(3):188-195. doi: 10.4077/CJP.2018.BAG567.
Strengthening exercise combined with blood flow restriction potentially increases muscle strength. This type of exercise does not require heavy weight liftings and is a feasible method to be performed by persons suffering illnesses. However, strengthening exercise may induce inflammatory responses due to muscle and vascular endothelial damage. This study aimed to investigate alterations of high-sensitivity C-reactive protein (hsCRP) and fibrinogen levels in healthy subjects after five weeks of low intensity resistance training (LIRT) with blood flow restriction (BFR) on increasing strength in comparison with high intensity resistance training (HIRT) and LIRT alone, and to evaluate aspects related to the relative safety of LIRT + BFR. Eighteen healthy subjects were randomized into 3 groups. The HIRT group: 70% of One-Repetition Maximum (1-RM); LIRT + BFR group: 30% of 1-RM with BFR (a modified 13-cm wide cuff was used); LIRT group: 30% of 1-RM. The peak torque of isokinetic contraction of the left elbow flexor in each subject was measured before and after 5 weeks of resistance exercises to determine any increases in the left biceps brachii muscle strength. Blood markers of homeostasis (fibrinogen) and inflammation (hsCRP) were also measured before and after five weeks of training. Significant increases of strength were demonstrated between the five weeks of resistance exercises in the HIRT group (P = 0.003) and the LIRT + BFR group (P = 0.001). Peak torque of isokinetic contraction of the left flexor elbow joint at 60° per second angular velocity showed that the LIRT + BFR group produced the greatest peak torque increase than the HIRT group. There were no significant changes in the hsCRP levels in all the groups (P > 0.05) after five weeks of intervention. No significant differences of fibrinogen levels were found in the HIRT group (P = 0.500) and the LIRT + BFR group (P = 0.405), but significant decreases were found in the fibrinogen levels in the LIRT group (P = 0.017). The LIRT + BFR increases in the muscle strength were as significant as in HIRT without altering the fibrinogen and hsCRP levels in the healthy subjects. In this study, LIRT + BFR showed increase muscle strength without any vascular problems.
强化训练结合血流限制可能会增强肌肉力量。这种训练方式不需要进行重物举重，对于患病者来说是一种可行的方法。然而，强化训练可能会因肌肉和血管内皮损伤而引发炎症反应。本研究旨在调查健康受试者在进行五周低强度抗阻训练（LIRT）并结合血流限制（BFR）以增强力量后，与高强度抗阻训练（HIRT）和单独的LIRT相比，高敏C反应蛋白（hsCRP）和纤维蛋白原水平的变化，并评估与LIRT + BFR相对安全性相关的方面。18名健康受试者被随机分为3组。HIRT组：一次重复最大值（1-RM）的70%；LIRT + BFR组：1-RM的30%并结合BFR（使用改良的13厘米宽袖带）；LIRT组：1-RM的30%。在进行5周抗阻训练前后，测量每个受试者左肘屈肌等速收缩的峰值扭矩，以确定肱二头肌力量是否增加。在训练5周前后，还测量了体内稳态（纤维蛋白原）和炎症（hsCRP）的血液标志物。在HIRT组（P = 0.003）和LIRT + BFR组（P = 0.001）的5周抗阻训练期间，力量有显著增加。在每秒60°角速度下左屈肘关节等速收缩的峰值扭矩表明，LIRT + BFR组的峰值扭矩增加幅度大于HIRT组。干预5周后，所有组的hsCRP水平均无显著变化（P > 0.05）。HIRT组（P = 0.500）和LIRT + BFR组（P = 0.405）的纤维蛋白原水平无显著差异，但LIRT组的纤维蛋白原水平显著降低（P = 0.017）。在健康受试者中，LIRT + BFR增加肌肉力量的效果与HIRT相当，且不会改变纤维蛋白原和hsCRP水平。在本研究中，LIRT + BFR显示出在不产生任何血管问题的情况下增加肌肉力量。
