Littlewood Katie, Gegic Jasleen, Hickman Mike, Henson Richard C J, Bishop Jaime R, Kershaw Tim, Diamond Patrick, Slabaugh Greg, Tranos Emmanouil, Vasilaki Aphrodite, Tennant Daniel, Courtin Emilie, Chan Li F, Henson Sian M
William Harvey Research Institute, Queen Mary University of London, London, EC1M 6BQ, UK.
Fleet Architects, London, E8 4RG, UK.
Aging Clin Exp Res. 2025 Jun 23;37(1):191. doi: 10.1007/s40520-025-03034-3.
The UK is experiencing a decline in healthy life expectancy, now at 62.4 years for men and 60.9 years for women. Socioeconomic deprivation plays a significant role in health disparities, affecting individuals across the life arc. Girls born in the most deprived areas may live 19 fewer years in good health compared to those in wealthier areas. Health inequalities are particularly severe for ethnic minorities, with Black and Asian individuals reporting poorer health at a younger age. Health inequalities correlate with socioeconomic status. In old age, 2.1 million older adults live in poverty, with Black and Asian communities again disproportionately affected. While ageing increases the risk of morbidities, poor health is not inevitable; however, disadvantaged populations face early-life risk factors, such as low birth weight, linked to future conditions like diabetes and cardiovascular disease. CELLO, an interdisciplinary network, focuses on cellular metabolism throughout life in disadvantaged populations, examining how both genetic and environmental factors shape metabolic dysfunction and contribute to social health inequalities. This review stems from discussions within the network, aiming to advance understanding of healthy ageing across the life course.
英国的健康预期寿命正在下降，目前男性为62.4岁，女性为60.9岁。社会经济剥夺在健康差距中起着重要作用，影响着人生各个阶段的个体。与富裕地区出生的女孩相比，最贫困地区出生的女孩健康状况良好的时间可能少19年。健康不平等在少数族裔中尤为严重，黑人和亚裔个体在年轻时的健康状况较差。健康不平等与社会经济地位相关。在老年群体中，有210万老年人生活在贫困中，黑人和亚裔社区再次受到不成比例的影响。虽然衰老会增加发病风险，但健康状况不佳并非不可避免；然而，弱势群体面临早期生命风险因素，如低出生体重，这与未来的糖尿病和心血管疾病等状况有关。CELLO是一个跨学科网络，专注于弱势群体一生中的细胞代谢，研究遗传和环境因素如何塑造代谢功能障碍并导致社会健康不平等。这篇综述源于该网络内部的讨论，旨在增进对整个生命历程中健康老龄化的理解。
