Miller G J, Beckles G L, Maude G H, Carson D C, Price S G
MRC Epidemiology and Medical Care Unit, Northwick Park Hospital, Harrow, Middlesex, United Kingdom.
J Epidemiol Community Health. 1990 Jun;44(2):136-8. doi: 10.1136/jech.44.2.136.
The aim of the study was to determine whether the inverse association between high density lipoprotein cholesterol concentration and risk of coronary heart disease described in people of European stock was also present in other racial groups.
The study was a prospective population survey. Cardiovascular risk factors were examined, including fasting serum lipid estimation (obtained at recruitment).
This was a community based study within a defined survey area in Trinidad.
All men aged between 35 and 69 years within the survey area were identified and followed between 1977 and 1986. Analysis was confined to those of African, Asian Indian, and mixed descent who were free of coronary heart disease at entry (n = 960, 69% of age eligible men in the survey population).
64 men developed coronary heart disease during the study period. A strong inverse curvilinear relation was found between high density lipoprotein cholesterol and coronary heart disease incidence (p less than 0.005), independent of age or other relevant characteristics including low density lipoprotein cholesterol.
A low serum concentration of high density lipoprotein cholesterol is a risk factor for coronary heart disease in non-whites as well as in whites.
本研究旨在确定在欧洲血统人群中所描述的高密度脂蛋白胆固醇浓度与冠心病风险之间的负相关关系在其他种族群体中是否也存在。
本研究为前瞻性人群调查。对心血管危险因素进行了检查，包括空腹血脂测定（在招募时获得）。
这是一项在特立尼达一个特定调查区域内基于社区的研究。
确定了调查区域内所有年龄在35至69岁之间的男性，并在1977年至1986年期间对其进行随访。分析仅限于那些在入组时无冠心病的非洲裔、亚洲印度裔和混血后裔（n = 960，占调查人群中符合年龄条件男性的69%）。
在研究期间，64名男性患上了冠心病。发现高密度脂蛋白胆固醇与冠心病发病率之间存在强烈的负向曲线关系（p < 0.005），不受年龄或其他相关特征（包括低密度脂蛋白胆固醇）的影响。
血清高密度脂蛋白胆固醇浓度低是白人以及非白人患冠心病的一个危险因素。
