Department of Chemistry, Shanghai Normal University, Shanghai 200234, China.
Mater Sci Eng C Mater Biol Appl. 2013 Aug 1;33(6):3166-72. doi: 10.1016/j.msec.2013.03.040. Epub 2013 Apr 1.
Hollow carbonated hydroxyapatite microspheres with mesoporous structure (HCHAs) have been fabricated by using calcium carbonated microspheres as sacrificial templates according to the following routes: (i) the in situ deposit of carbonated hydroxyapatite on the surfaces of CaCO3 microspheres by hydrothermal method and (ii) the removal of CaCO3 by chemical etching. The HCHAs consist of a hollow core and a mesoporous shell. Interestingly, the shell of the microspheres is constructed by carbonated hydroxyapatite nanoplates as building blocks. Moreover, these nanoplates are composed of many smaller nanoparticles with different crystal orientations, and the mesopores exist among these nanoparticles. The HCHAs exhibit the high drug-loading capacity and sustained drug release property, suggesting that the hierarchically porous microspheres have great potentials for bone-implantable drug-delivery applications.
中空碳酸羟基磷灰石介孔微球（HCHAs）是通过以碳酸钙微球为牺牲模板，采用以下路线制备的：（i）通过水热法在 CaCO3 微球表面原位沉积碳酸羟基磷灰石，以及（ii）通过化学刻蚀去除 CaCO3。HCHAs 由中空核和介孔壳组成。有趣的是，微球的壳由碳酸羟基磷灰石纳米板作为构建块构成。此外，这些纳米板由具有不同晶体取向的许多较小的纳米颗粒组成，并且介孔存在于这些纳米颗粒之间。HCHAs 表现出高载药能力和持续的药物释放性能，表明分级多孔微球在骨植入药物输送应用中具有巨大的潜力。
