Sonda L P, Mazo R, Chancellor M B
Division of Urology, University of Michigan Medical Center, Ann Arbor 48109.
J Sex Marital Ther. 1990 Spring;16(1):15-21. doi: 10.1080/00926239008405962.
A double-blind crossover study of yohimbine vs. placebo was carried out in 40 patients. Eleven of 33 patients (33%) who completed the study had subjective improvement of erection while taking yohimbine alone, five of 33 (15%) responded while taking both yohimbine and placebo, five of 33 (15%) responded to placebo alone, and 12 of 33 (36%) responded to neither. Of 215 impotent patients subsequently treated with yohimbine, 38% reported some subjective improvement, but only 5% were completely satisfied. The physiologic response of yohimbine appears to occur in the central nervous system. Recent experience suggests that the typical dose has little side effect and higher doses achieves better results, but this conclusion requires more evaluation.
对40名患者进行了育亨宾与安慰剂的双盲交叉研究。完成研究的33名患者中，11名（33%）仅服用育亨宾时勃起有主观改善，33名中的5名（15%）在同时服用育亨宾和安慰剂时有反应，33名中的5名（15%）仅对安慰剂有反应，33名中的12名（36%）对两者均无反应。在随后接受育亨宾治疗的215名阳痿患者中，38%报告有一些主观改善，但只有5%完全满意。育亨宾的生理反应似乎发生在中枢神经系统。最近的经验表明，典型剂量副作用小，较高剂量效果更好，但这一结论需要更多评估。
