INSERM, U1018, Centre for Research in Epidemiology and Population Health, Epidemiology of Occupational and Social Determinants of Health, Villejuif F-94807, France; Université de Versailles St Quentin, UMRS 1018, Villejuif F-94807, France.
Psychoneuroendocrinology. 2013 Oct;38(10):2309-18. doi: 10.1016/j.psyneuen.2013.04.018. Epub 2013 May 23.
Studies on the association between homocysteine levels and depression have shown conflicting results. To examine the association between serum total homocysteine (tHcy) levels and major depressive disorder (MDD) in a large community sample with an extended age range.
A total of 3392 men and women aged 35-66 years participating in the CoLaus study and its psychiatric arm (PsyCoLaus) were included in the analyses. High tHcy measured from fasting blood samples was defined as a concentration ≥15μmol/L. MDD was assessed using the semi-structured Diagnostic Interview for Genetics Studies.
In multivariate analyses, elevated tHcy levels were associated with greater odds of meeting the diagnostic criteria for lifetime MDD among men (OR=1.71; 95% CI, 1.18-2.50). This was particularly the case for remitted MDD. Among women, there was no significant association between tHcy levels and MDD and the association tended to be in the opposite direction (OR=0.61; 95% CI, 0.34-1.08).
In this large population-based study, elevated tHcy concentrations are associated with lifetime MDD and particularly with remitted MDD among men.
关于同型半胱氨酸水平与抑郁症之间关联的研究结果相互矛盾。本研究旨在探究在一个年龄跨度较大的大型社区样本中，血清总同型半胱氨酸（tHcy）水平与重度抑郁症（MDD）之间的关联。
共纳入 3392 名年龄在 35-66 岁的 CoLaus 研究及其精神科分支（PsyCoLaus）参与者，对其进行分析。采用空腹血样检测高 tHcy，定义为浓度≥15μmol/L。采用半结构式遗传研究诊断访谈对 MDD 进行评估。
多变量分析显示，tHcy 水平升高与男性终生 MDD 诊断标准的可能性更大相关（OR=1.71；95%CI，1.18-2.50）。这种情况在缓解的 MDD 中尤其明显。在女性中，tHcy 水平与 MDD 之间无显著关联，且关联趋势相反（OR=0.61；95%CI，0.34-1.08）。
在这项大型基于人群的研究中，tHcy 浓度升高与男性的终生 MDD 相关，特别是与缓解的 MDD 相关。
