Department of Psychiatry, Faculty of Medicine in Hradec Kralove, Charles University and University Hospital Hradec Kralove, Hradec Kralove, Czech Republic.
Department of Ophthalmology, Faculty of Medicine in Hradec Kralove, Charles University and University Hospital Hradec Kralove, Hradec Kralove, Czech Republic.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2024 Jun;168(2):147-155. doi: 10.5507/bp.2023.026. Epub 2023 Jul 17.
The aim of our study was to find a possible association between retinal microvascular abnormality and major depression in a non-geriatric population.
The participants with major depression were hospitalised at the University Hospital in Hradec Kralove, Department of Psychiatry. Retinal images were obtained using a stationary Fundus camera FF450 by Zeiss and a hand-held camera by oDocs.
Fifty patients (men n=18, women n=32) aged 16 to 55 (men's average age 33.7±9.9 years, women's average age 37.9±11.5 years) were compared with fifty mentally healthy subjects (men n=28, women n=22) aged 18 to 61 (men's average age 35.3±9.2 years, women's average age 36.6±10.6 years) in a cross-sectional design. The patients were diagnosed with a single depressive episode (n=26) or a recurrent depressive disorder (n=24) according to the ICD-10 classification. Our results confirmed significant microvascular changes in the retina in patients with depressive disorder in comparison to the control group of mentally healthy subjects, with significantly larger arteriolar (P<0.0001) as well as venular (P<0.001-0.0001) calibres in major depression.
According to the literature, acute and chronic neuroinflammation is associated with changes in microvascular form and function. The endothelium becomes a major participant in the inflammatory response damaging the surrounding tissue and its function. Because the retina and brain tissue share a common embryonic origin, we suspect similar microvascular pathology in the retina and in the brain in major depression. Our results may contribute to a better understanding of depression etiopathogenesis and to its personalized treatment.
我们的研究旨在非老年人群中寻找视网膜微血管异常与重度抑郁症之间的可能关联。
在赫拉德茨-克拉洛韦大学医院精神病学部住院的重度抑郁症患者参与了这项研究。使用蔡司的固定式眼底照相机 FF450 和 oDocs 的手持式相机获取视网膜图像。
在横断面设计中，我们将 50 名年龄在 16 至 55 岁之间的抑郁症患者（男性 n=18，女性 n=32）与 50 名年龄在 18 至 61 岁之间的心理健康对照者（男性 n=28，女性 n=22）进行了比较。患者根据 ICD-10 分类被诊断为单次发作性抑郁（n=26）或复发性抑郁障碍（n=24）。与对照组相比，我们的结果证实了抑郁症患者视网膜的微血管发生了显著变化，表现为明显更大的小动脉（P<0.0001）和小静脉（P<0.001-0.0001）口径。
根据文献，急性和慢性神经炎症与微血管形态和功能的变化有关。内皮细胞成为炎症反应的主要参与者，破坏周围组织及其功能。由于视网膜和脑组织具有共同的胚胎起源，我们怀疑在重度抑郁症中，视网膜和大脑中存在类似的微血管病理学。我们的研究结果可能有助于更好地理解抑郁症的发病机制，并为其提供个性化的治疗方法。
