Alam Kiran, Jain Anshu, Misra Aroonima, Khan A H
Department of Pathology, JN Medical College, Aligarh, Uttar Pradesh, India.
BMJ Case Rep. 2013 May 23;2013:bcr2012008435. doi: 10.1136/bcr-2012-008435.
We present a case of a 15-year-old girl with a pulsatile, rapidly enlarging mass at the root of the nose suspected to be malignant. Excisional biopsy showed worrisome histological features; however, a final diagnosis of cellular schwannoma was reached excluding the possibility of malignant peripheral nerve sheath tumour by histological and immunohistochemical attributes. Cellular schwannoma, a pseudosarcomatous entity, is a rare benign neoplasm that may cause bone erosion and may be mistaken for a malignancy, clinically and histologically. Diagnosis of cellular schwannoma is essential to prevent mismanagement as it never metastasises and responds to local excision as opposed to aggressive treatment required by a malignant neoplasm.
我们报告一例15岁女孩，其鼻根部有一个搏动性、迅速增大的肿块，怀疑为恶性。切除活检显示出令人担忧的组织学特征；然而，通过组织学和免疫组化特征最终诊断为细胞性神经鞘瘤，排除了恶性外周神经鞘瘤的可能性。细胞性神经鞘瘤是一种假肉瘤性病变，是一种罕见的良性肿瘤，可导致骨质侵蚀，在临床和组织学上可能被误诊为恶性肿瘤。细胞性神经鞘瘤的诊断对于防止管理不当至关重要，因为它从不转移，对局部切除有反应，而不像恶性肿瘤那样需要积极治疗。
