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模拟恶性外周神经鞘瘤的腭部细胞性施万瘤：一场诊断马拉松。

Cellular Schwannoma of the Palate Simulating as Malignant Peripheral Nerve Sheath Tumor: A Diagnostic Marathon.

作者信息

Bajpai Manas, Mani Amit, L Sabnis Saurabh, Rani Rm Vatchala

机构信息

Dept. of Oral and Maxillofacial Pathology and Oral Microbiology, Rural Dental College Pravara Institute of Medical Sciences, Loni (Maharashtra), India.

Dept. of Periodontology, Rural Dental College, Pravara Institute of Medical Sciences, Loni (Maharashtra) India.

出版信息

J Dent (Shiraz). 2024 Dec 1;25(4):383-387. doi: 10.30476/dentjods.2024.101035.2265. eCollection 2024 Dec.

DOI:10.30476/dentjods.2024.101035.2265
PMID:39713108
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11662178/
Abstract

Schwannomas are considered benign soft tissue tumors that originate from Schwann cells. Oral Schwannomas are rare and account for only 1% of all Schwannomas. Cellularschwannoma (CS) is a rare histological variant of schwannoma, characterized by high cellularity and cellular atypia. We present a case of localized growth of palatal mucosa that imitated the features of malignant peripheral nerve sheath tumor (MPNST) on histopathological examination; it was differentiated from MPNST by the correlation of clinical, histopathological, and immunohistochemical features.

摘要

神经鞘瘤被认为是起源于施万细胞的良性软组织肿瘤。口腔神经鞘瘤较为罕见，仅占所有神经鞘瘤的1%。细胞性神经鞘瘤（CS）是神经鞘瘤一种罕见的组织学变异型，其特征为细胞密度高和细胞异型性。我们报告一例腭黏膜局限性生长病例，该病例在组织病理学检查中表现出恶性外周神经鞘膜瘤（MPNST）的特征；通过临床、组织病理学和免疫组化特征的相关性，将其与MPNST区分开来。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6c4/11662178/3e18800ab5e8/JDS-25-383-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6c4/11662178/bdecbda0bfee/JDS-25-383-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6c4/11662178/29b7c10f911d/JDS-25-383-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6c4/11662178/3e18800ab5e8/JDS-25-383-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6c4/11662178/bdecbda0bfee/JDS-25-383-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6c4/11662178/29b7c10f911d/JDS-25-383-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6c4/11662178/3e18800ab5e8/JDS-25-383-g003.jpg

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本文引用的文献

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Intraoral Cellular Schwannoma Involving Maxillary Gingiva: A Rare Case Report.累及上颌牙龈的口腔内细胞性施万瘤：一例罕见病例报告
Front Dent. 2023 Sep 25;20:36. doi: 10.18502/fid.v20i36.13682. eCollection 2023.
2
Diagnostic Significance of Ki67 Staining Pattern in Benign Peripheral Nerve Sheath Tumors: An Additional Diagnostic Tool.Ki67 染色模式在良性周围神经鞘瘤中的诊断意义：一种附加的诊断工具。
Int J Surg Pathol. 2023 Oct;31(7):1225-1231. doi: 10.1177/10668969221143456. Epub 2022 Dec 7.
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Intracranial cellular schwannomas: a clinicopathological study of 20 cases.
颅内细胞性 schwann 瘤：20 例临床病理研究。
Histopathology. 2020 Jan;76(2):275-282. doi: 10.1111/his.13967. Epub 2019 Nov 13.
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Ancient schwannoma of gingiva - A rare case report.牙龈古老型神经鞘瘤——1例罕见病例报告
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An unusual case of neural palatal swelling.一例罕见的神经性腭部肿胀病例。
Int J Health Sci (Qassim). 2017 Jul-Sep;11(3):71-73.
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Loss of H3K27 trimethylation distinguishes malignant peripheral nerve sheath tumors from histologic mimics.H3K27三甲基化的缺失可将恶性外周神经鞘瘤与组织学上的相似肿瘤区分开来。
Mod Pathol. 2016 Jan;29(1):4-13. doi: 10.1038/modpathol.2015.134. Epub 2015 Nov 20.
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Morphologic and immunohistochemical features of malignant peripheral nerve sheath tumors and cellular schwannomas.恶性外周神经鞘膜瘤和细胞性神经鞘瘤的形态学及免疫组化特征
Mod Pathol. 2015 Feb;28(2):187-200. doi: 10.1038/modpathol.2014.109. Epub 2014 Sep 5.
8
Cellular schwannoma masquerading as malignant peripheral nerve sheath tumour: a diagnostic dilemma.伪装成恶性外周神经鞘瘤的细胞性施万瘤：诊断难题
BMJ Case Rep. 2013 May 23;2013:bcr2012008435. doi: 10.1136/bcr-2012-008435.
9
Identification of p53 as a strong predictor of survival for patients with malignant peripheral nerve sheath tumors.鉴定p53作为恶性外周神经鞘膜瘤患者生存的强预测指标。
Neuro Oncol. 2009 Oct;11(5):514-28. doi: 10.1215/15228517-2008-127. Epub 2009 Jan 30.
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Cellular schwannoma in the oral mucosa.
Acta Otolaryngol. 2002 Jun;122(4):458-62. doi: 10.1080/00016480260000210.