Almeida Jackson Roberto Guedes da Silva, Souza Grasielly Rocha, Silva Juliane Cabral, Saraiva Sarah Raquel Gomes de Lima, Júnior Raimundo Gonçalves de Oliveira, Quintans Jullyana de Souza Siqueira, Barreto Rosana de Souza Siqueira, Bonjardim Leonardo Rigoldi, Cavalcanti Sócrates Cabral de Holanda, Quintans Lucindo José
Núcleo de Estudos e Pesquisas de Plantas Medicinais, Universidade Federal do Vale do São Francisco, 56.304-205 Petrolina, PE, Brazil.
ScientificWorldJournal. 2013 Apr 18;2013:808460. doi: 10.1155/2013/808460. Print 2013.
Borneol, a bicyclic monoterpene, has been evaluated for antinociceptive and anti-inflammatory activities. Antinociceptive and anti-inflammatory activities were studied by measuring nociception by acetic acid, formalin, hot plate, and grip strength tests, while inflammation was prompted by carrageenan-induced peritonitis. The rotarod test was used to evaluate motor coordination. Borneol produced a significant (P < 0.01) reduction of the nociceptive behavior at the early and late phases of paw licking and reduced the writhing reflex in mice (formalin and writhing tests, resp.). When the hot plate test was conducted, borneol (in higher dose) produced an inhibition (P < 0.05) of the nociceptive behavior. Such results were unlikely to be provoked by motor abnormality. Additionally, borneol-treated mice reduced the carrageenan-induced leukocytes migration to the peritoneal cavity. Together, our results suggest that borneol possess significant central and peripheral antinociceptive activity; it has also anti-inflammatory activity. In addition, borneol did not impair motor coordination.
冰片，一种双环单萜，已被评估其抗伤害感受和抗炎活性。通过乙酸、福尔马林、热板和握力测试来测量伤害感受，以此研究抗伤害感受和抗炎活性，同时角叉菜胶诱导的腹膜炎引发炎症。使用转棒试验评估运动协调性。冰片在舔爪的早期和晚期显著（P < 0.01）降低伤害感受行为，并减少小鼠的扭体反射（分别为福尔马林和扭体试验）。进行热板试验时，冰片（高剂量）对伤害感受行为产生抑制作用（P < 0.05）。这些结果不太可能由运动异常引起。此外，用冰片处理的小鼠减少了角叉菜胶诱导的白细胞向腹腔的迁移。总之，我们的结果表明冰片具有显著的中枢和外周抗伤害感受活性；它也具有抗炎活性。此外，冰片不会损害运动协调性。
