Roato Ilaria
CeRMS, A.O. Città della Salute e della Scienza, Via Santena 5, 10126 Torino, Italy.
Clin Dev Immunol. 2013;2013:315024. doi: 10.1155/2013/315024. Epub 2013 Apr 24.
Bone metastases are a dismal consequence for different types of solid tumors, such as breast, prostate, lung, and kidney cancer. The mechanisms regulating the interactions among bone, immune system, and tumor cells have been deeply investigated, and many studies are ongoing to define the specific role of the different cells in the bone metastatic process. The affinity of some tumors to growth in bone results from the special microenvironment provided by bone. Moreover, immune system and bone have a bidirectional relationship: bone cells express surface molecules ruling the expansion of hemopoietic stem cells from which all cells of the mammalian immune system derive, and various immunoregulatory cytokines influence the fate of bone cells. The last findings allow to extend the concept of vicious cycle and add T cells as mediators of the tumor growth in bone.
骨转移是不同类型实体瘤（如乳腺癌、前列腺癌、肺癌和肾癌）的一个不良后果。调节骨、免疫系统和肿瘤细胞之间相互作用的机制已得到深入研究，并且许多研究正在进行，以确定不同细胞在骨转移过程中的具体作用。一些肿瘤对在骨中生长的亲和力源于骨所提供的特殊微环境。此外，免疫系统和骨存在双向关系：骨细胞表达调控造血干细胞增殖的表面分子，而哺乳动物免疫系统的所有细胞均来源于造血干细胞，并且各种免疫调节细胞因子会影响骨细胞的命运。最新研究结果使恶性循环的概念得以扩展，并将T细胞添加为骨中肿瘤生长的介质。
