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一名慢性淋巴细胞白血病患者因五日热巴尔通体感染导致杆菌性血管瘤病和菌血症。

Bacillary Angiomatosis and Bacteremia due to Bartonella quintana in a Patient with Chronic Lymphocytic Leukemia.

作者信息

Fulchini Rosamaria, Bloemberg Guido, Boggian Katia

机构信息

Division of Infectious Diseases, Department of Internal Medicine, Cantonal Hospital of St. Gallen, 9007 St. Gallen, Switzerland.

出版信息

Case Rep Infect Dis. 2013;2013:694765. doi: 10.1155/2013/694765. Epub 2013 Apr 28.

DOI:10.1155/2013/694765
PMID:23710386
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3655512/
Abstract

We present a 63-year-old man treated with alemtuzumab for chronic lymphocytic leukemia who developed multiple angiomatous papules and fever. Real-time polymerase chain reaction (RT-PCR) from a skin lesion and blood sample revealed Bartonella quintana as causative agent confirming the diagnosis of bacillary angiomatosis with bacteremia. Treatment with doxycycline, initially in combination with gentamicin, led to complete resolution of the lesions. This case shows the importance of considering bacillary angiomatosis as a rare differential diagnosis of angiomatous lesions in the immunocompromised patient, particularly in chronic lymphocytic leukemia and following lymphocyte depleting treatments as alemtuzumab.

摘要

我们报告了一名63岁接受阿仑单抗治疗慢性淋巴细胞白血病的男性患者，该患者出现了多个血管瘤样丘疹和发热症状。对皮肤病变和血液样本进行的实时聚合酶链反应（RT-PCR）检测显示，五日热巴尔通体为病原体，从而确诊了菌血症性杆菌性血管瘤病。最初使用强力霉素联合庆大霉素进行治疗，使病变完全消退。该病例表明，对于免疫功能低下的患者，尤其是慢性淋巴细胞白血病患者以及接受如阿仑单抗等淋巴细胞清除治疗后的患者，将杆菌性血管瘤病作为血管瘤样病变的一种罕见鉴别诊断加以考虑具有重要意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ceec/3655512/5898260736e0/CRIM.ID2013-694765.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ceec/3655512/29e4cedd1d68/CRIM.ID2013-694765.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ceec/3655512/2a991f75fd94/CRIM.ID2013-694765.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ceec/3655512/2a562c4938c6/CRIM.ID2013-694765.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ceec/3655512/69c9197d95b3/CRIM.ID2013-694765.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ceec/3655512/5898260736e0/CRIM.ID2013-694765.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ceec/3655512/29e4cedd1d68/CRIM.ID2013-694765.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ceec/3655512/2a991f75fd94/CRIM.ID2013-694765.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ceec/3655512/2a562c4938c6/CRIM.ID2013-694765.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ceec/3655512/69c9197d95b3/CRIM.ID2013-694765.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ceec/3655512/5898260736e0/CRIM.ID2013-694765.005.jpg

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