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亚硝酸盐：一氧化氮的生理储存库及线粒体功能调节剂。

Nitrite: A Physiological Store of Nitric Oxide and Modulator of Mitochondrial Function.

作者信息

Shiva Sruti

机构信息

Vascular Medicine Institute and Department of Pharmacology & Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15261.

出版信息

Redox Biol. 2013;1(1):40-44. doi: 10.1016/j.redox.2012.11.005.

DOI:10.1016/j.redox.2012.11.005
PMID:23710434
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3661298/
Abstract

Nitrite, long considered a biologically inert metabolite of nitric oxide (NO) oxidation, is now accepted as a physiological storage pool of NO that can be reduced to bioactive NO in hypoxic conditions to mediate a spectrum of physiological responses in blood and tissue. This graphical review will provide a broad overview of the role of nitrite in physiology, focusing on its formation and reduction to NO as well as its regulation of the mitochondrion- an emerging subcellular target for its biological actions in tissues.

摘要

亚硝酸盐长期以来被认为是一氧化氮（NO）氧化的生物惰性代谢产物，现在被公认为是NO的生理储存库，在缺氧条件下可还原为具有生物活性的NO，从而介导血液和组织中的一系列生理反应。本图文综述将广泛概述亚硝酸盐在生理学中的作用，重点关注其生成、还原为NO的过程以及对线粒体的调节——线粒体是其在组织中发挥生物学作用的一个新兴亚细胞靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6d7/3757707/5ae7e7cfda3c/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6d7/3757707/9a337a0ab415/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6d7/3757707/d977f8065038/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6d7/3757707/12e47288706f/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6d7/3757707/5ae7e7cfda3c/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6d7/3757707/9a337a0ab415/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6d7/3757707/d977f8065038/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6d7/3757707/12e47288706f/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6d7/3757707/5ae7e7cfda3c/gr4.jpg

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Free Radic Biol Med. 2012 Oct 1;53(7):1440-50. doi: 10.1016/j.freeradbiomed.2012.07.080. Epub 2012 Aug 4.
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Nitrite regulates hypoxic vasodilation via myoglobin-dependent nitric oxide generation.亚硝酸盐通过肌红蛋白依赖性一氧化氮生成调节缺氧性血管舒张。
Circulation. 2012 Jul 17;126(3):325-34. doi: 10.1161/CIRCULATIONAHA.111.087155. Epub 2012 Jun 9.
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Nitrite-generated NO circumvents dysregulated arginine/NOS signaling to protect against intimal hyperplasia in Sprague-Dawley rats.
腹部大手术对骨骼肌线粒体呼吸的影响及其与全身氧化还原状态和心肺功能的关系。
Exp Biol Med (Maywood). 2025 Feb 21;250:10254. doi: 10.3389/ebm.2025.10254. eCollection 2025.
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Emerging strategies for nitric oxide production and their topical application as nanodressings to promote diabetic wound healing.一氧化氮产生的新兴策略及其作为纳米敷料的局部应用以促进糖尿病伤口愈合。
J Nanobiotechnology. 2025 Jan 29;23(1):53. doi: 10.1186/s12951-025-03135-1.
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Impaired Endothelium-Dependent Vasodilation and Increased Levels of Soluble Fms-like Tyrosine Kinase-1 Induced by Reduced Uterine Perfusion Pressure in Pregnant Rats: Evidence of Protective Effects with Sodium Nitrite Treatment in Preeclampsia.在患有先兆子痫的怀孕大鼠中，降低子宫灌注压可导致内皮依赖性血管舒张功能受损和可溶性 Fms 样酪氨酸激酶-1 水平升高：亚硝酸钠治疗的保护作用证据。
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