吸烟与特应性皮炎之间的剂量反应关系：一项青少年大型横断面研究的结果。
Dose-response association between smoking and atopic eczema: results from a large cross-sectional study in adolescents.
机构信息
Allergy and Immunology Clinic, Pulmonary Institute, Rabin Medical Center Petach Tikva, affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
出版信息
Dermatology. 2013;226(3):195-9. doi: 10.1159/000348333. Epub 2013 May 24.
BACKGROUND
Tobacco smoking and exposure to environmental tobacco smoke (ETS) are known risk factors for asthma, but their association with atopic eczema is unclear.
OBJECTIVE
To investigate the association of smoking and exposure to ETS with prevalence of atopic eczema in a national sample of 13- to 14-year-olds in Israel.
METHODS
Cross-sectional study within the framework of the International Study on Asthma and Allergies in Childhood.
RESULTS
Complete data were available for 10,298 schoolchildren. Atopic eczema as well as asthma and allergic rhinitis were significantly more prevalent in smokers than nonsmokers. Multiple regression analysis revealed a dose-response association between smoking and atopic eczema compared to not smoking: occasional smokers, odds ratio (OR) = 1.6 (95% confidence interval (CI) = 1.2-2.3); daily smokers, OR = 2.2 (95% CI = 1.4-3.6). Exposure to ETS at home was significantly associated with asthma (OR = 1.25; 95% CI = 1.1-1.5) but not atopic eczema.
CONCLUSIONS
The dose-response association between active smoking and atopic eczema in adolescents is a novel observation which deserves further consideration.
背景
吸烟和接触环境烟草烟雾（ETS）已知是哮喘的危险因素，但它们与特应性皮炎的关系尚不清楚。
目的
在以色列的一个 13-14 岁儿童的全国样本中，调查吸烟和接触 ETS 与特应性皮炎患病率之间的关系。
方法
在儿童哮喘和过敏国际研究的框架内进行的横断面研究。
结果
共有 10298 名在校儿童提供了完整的数据。吸烟者中特应性皮炎以及哮喘和过敏性鼻炎的患病率明显高于不吸烟者。多变量回归分析显示，与不吸烟者相比，吸烟与特应性皮炎之间存在剂量反应关系：偶尔吸烟者，比值比（OR）=1.6（95%置信区间（CI）=1.2-2.3）；每日吸烟者，OR=2.2（95%CI=1.4-3.6）。在家中接触 ETS 与哮喘显著相关（OR=1.25；95%CI=1.1-1.5），但与特应性皮炎无关。
结论
青少年中主动吸烟与特应性皮炎之间的剂量反应关系是一个新的观察结果，值得进一步考虑。
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