Division of Pediatric Allergy-Immunology, Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA.
Allergol Int. 2013 Jun;62(2):151-61. doi: 10.2332/allergolint.13-RAI-0564.
Atopic dermatitis (AD) is a chronic inflammatory skin disease that is often associated with the development of food allergy and asthma. New insights into AD reveals an important role for structural abnormalities in the epidermis resulting in a leaky epithelial barrier as well as chronic immune activation that contribute to the pathophysiology of this common skin disease. Patients with AD have a predisposition to colonization or infection by microbial organisms, most notably Staphylococcus aureus and herpes simplex virus (HSV). Measures directed at healing and protecting the skin barrier and controlling the immune activation are needed for effective management of AD. Early intervention may improve outcomes for AD as well as reduce the systemic allergen sensitization that may lead to associated allergic diseases in other organs.
特应性皮炎（AD）是一种慢性炎症性皮肤病，常与食物过敏和哮喘的发展有关。AD 的新见解揭示了表皮结构异常在导致上皮屏障通透性增加以及慢性免疫激活方面的重要作用，这有助于理解这种常见皮肤病的病理生理学。AD 患者容易被微生物定植或感染，最常见的是金黄色葡萄球菌和单纯疱疹病毒（HSV）。需要采取措施来修复和保护皮肤屏障，控制免疫激活，以有效管理 AD。早期干预可能改善 AD 的预后，并减少可能导致其他器官相关过敏性疾病的全身性过敏原致敏。
