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一例由抗-Hro和抗-e引起的新生儿溶血病。

A case of hemolytic disease of the newborn caused by anti-Hro and anti-e.

作者信息

Diao Y, Song N, Guan Z, Zhang L, Wang Y, Wan M

机构信息

Institute of Blood Transfusion, CAMS, Chengdu.

出版信息

Proc Chin Acad Med Sci Peking Union Med Coll. 1990;5(1):58-60.

PMID:2371267
Abstract

A Chinese woman of blood group B, D- and her husband of blood group AB, CCDee were examined. The woman had not been transfused before. Their first two babies died. Anti-Hro and anti-e were found in the mother's serum. During her third pregnancy, the titer of antibodies went up quickly, approximately one titer per month. After 36 weeks of pregnancy, the baby was delivered by Caesarean section. The cord blood Hb was 88 g/L, his red blood cell count 2.7 x 10(12)/L, and total bilirubin 114.6 mol/L. The baby was of blood group AB, and CDe-D-genotype. Exchange transfusion was begun 2.5 hours after birth. O, ccDEE washed red cells together with group AB plasma were used. Two days later, 70 ml washed O, ccDEE concentrated red cells were administered. The baby is alive and in good health.

摘要

对一名B型、D阴性的中国女性及其AB型、CCDEE的丈夫进行了检查。该女性此前未接受过输血。他们的前两个孩子夭折。在母亲血清中发现了抗Hro和抗e抗体。在她第三次怀孕期间,抗体效价迅速上升,大约每月上升一个效价。怀孕36周后,通过剖宫产分娩出婴儿。脐带血血红蛋白为88g/L,红细胞计数为2.7×10¹²/L,总胆红素为114.6μmol/L。婴儿血型为AB型,CDe-D基因型。出生后2.5小时开始进行换血治疗。使用O型、ccDEE洗涤红细胞与AB型血浆混合。两天后,输注了70ml洗涤过的O型、ccDEE浓缩红细胞。婴儿存活且健康状况良好。

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1
A case of hemolytic disease of the newborn caused by anti-Hro and anti-e.一例由抗-Hro和抗-e引起的新生儿溶血病。
Proc Chin Acad Med Sci Peking Union Med Coll. 1990;5(1):58-60.
2
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[Haemolytic disease of the newborn--from a mother with anti-Kell, anti-E and anti-Vel anti-erythrocyte alloantibodies].[新生儿溶血病——源于一位携带抗Kell、抗E和抗Vel红细胞同种抗体的母亲]
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引用本文的文献

1
The Outcome of Hemolytic Disease of the Fetus and Newborn Caused by Anti-Rh17 Antibody: Analysis of Three Cases and Review of the Literature.抗Rh17抗体所致胎儿及新生儿溶血病的结局:三例分析并文献复习
Transfus Med Hemother. 2020 Jun;47(3):264-271. doi: 10.1159/000503012. Epub 2019 Oct 3.
2
Successful management of fetal hemolytic disease due to strong anti-Rh17 with plasma exchange and intrauterine transfusion in a woman with the D-- phenotype.成功治疗 D--表型女性因抗 Rh17 效价高导致的胎儿溶血病:采用血浆置换和宫内输血。
Int J Hematol. 2020 Jan;111(1):149-154. doi: 10.1007/s12185-019-02735-6. Epub 2019 Sep 19.
3
A case of rare anti-Hro alloantibody in a tertiary care center in India.
印度一家三级医疗中心的一例罕见抗-Hro同种抗体病例。
Asian J Transfus Sci. 2019 Jan-Jun;13(1):54-56. doi: 10.4103/ajts.AJTS_26_18.