Institute of Materials Research and Engineering, 3 Research Link, Singapore 117602.
Adv Healthc Mater. 2013 Dec;2(12):1571-5. doi: 10.1002/adhm.201300077. Epub 2013 May 28.
Multifunctional polymeric nano- and microparticles are engineered as theranostic carriers and their selective size-dependent cellular uptake is demonstrated. It is found that effective uptake and accumulation of nanoparticles occurs in both normal and cancer cells, whereas, that of microparticles occurs in cancer cells but not in normal cells, allowing cancer cells to be specifically targeted for local drug delivery.
多功能聚合物纳米和微米颗粒被设计为治疗诊断载体，并证明了它们的选择性尺寸依赖性细胞摄取。研究发现，纳米颗粒能够有效地被正常细胞和癌细胞摄取和积累，而微米颗粒只能被癌细胞摄取，不能被正常细胞摄取，从而可以特异性地靶向癌细胞进行局部药物递送。
