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基于壳聚糖的智能诊疗纳米复合材料实现了 pH 敏感药物释放，并结合磁共振成像进行癌症治疗。

Chitosan-based intelligent theragnosis nanocomposites enable pH-sensitive drug release with MR-guided imaging for cancer therapy.

机构信息

Department of Radiology, College of Medicine, Yonsei University, Seoul 120-752, South Korea.

出版信息

Nanoscale Res Lett. 2013 Nov 8;8(1):467. doi: 10.1186/1556-276X-8-467.

DOI:10.1186/1556-276X-8-467
PMID:24206754
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4226245/
Abstract

Smart drug delivery systems that are triggered by environmental conditions have been developed to enhance cancer therapeutic efficacy while limiting unwanted effects. Because cancer exhibits abnormally high local acidities compared to normal tissues (pH 7.4) due to Warburg effects, pH-sensitive systems have been researched for effective cancer therapy. Chitosan-based intelligent theragnosis nanocomposites, N-naphthyl-O-dimethymaleoyl chitosan-based drug-loaded magnetic nanoparticles (NChitosan-DMNPs), were developed in this study. NChitosan-DMNPs are capable of pH-sensitive drug release with MR-guided images because doxorubicin (DOX) and magnetic nanocrystals (MNCs) are encapsulated into the designed N-naphthyl-O-dimethymaleoyl chitosan (N-nap-O-MalCS). This system exhibits rapid DOX release as acidity increases, high stability under high pH conditions, and sufficient capacity for diagnosing and monitoring therapeutic responses. These results demonstrate that NChitosan-DMNPs have potential as theragnosis nanocomposites for effective cancer therapy.

摘要

智能药物输送系统可根据环境条件触发，旨在提高癌症治疗效果，同时限制不良反应。由于癌症由于瓦博格效应而表现出比正常组织（pH 7.4）更高的局部酸度，因此已经研究了 pH 敏感系统以进行有效的癌症治疗。本研究开发了基于壳聚糖的智能诊断治疗纳米复合材料、N-萘基-O-二甲马来酰基壳聚糖载药磁性纳米颗粒（NChitosan-DMNPs）。NChitosan-DMNPs 能够进行 pH 敏感药物释放和磁共振成像引导，因为阿霉素（DOX）和磁性纳米晶体（MNCs）被包裹在设计的 N-萘基-O-二甲马来酰基壳聚糖（N-nap-O-MalCS）中。该系统在酸度增加时表现出快速的 DOX 释放、在高 pH 条件下的高稳定性和诊断及监测治疗反应的充足能力。这些结果表明，NChitosan-DMNPs 有潜力成为用于有效癌症治疗的诊断治疗纳米复合材料。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9916/4226245/bb88a5e8065d/1556-276X-8-467-10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9916/4226245/a303375d3d01/1556-276X-8-467-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9916/4226245/12dd57f081a3/1556-276X-8-467-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9916/4226245/8675f54358c2/1556-276X-8-467-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9916/4226245/771d81640305/1556-276X-8-467-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9916/4226245/c6a94472592c/1556-276X-8-467-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9916/4226245/7cc61e23fe8b/1556-276X-8-467-6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9916/4226245/bd6a89e20b36/1556-276X-8-467-7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9916/4226245/d3b932f92717/1556-276X-8-467-8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9916/4226245/b12608186f4f/1556-276X-8-467-9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9916/4226245/bb88a5e8065d/1556-276X-8-467-10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9916/4226245/a303375d3d01/1556-276X-8-467-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9916/4226245/12dd57f081a3/1556-276X-8-467-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9916/4226245/8675f54358c2/1556-276X-8-467-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9916/4226245/771d81640305/1556-276X-8-467-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9916/4226245/c6a94472592c/1556-276X-8-467-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9916/4226245/7cc61e23fe8b/1556-276X-8-467-6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9916/4226245/bd6a89e20b36/1556-276X-8-467-7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9916/4226245/d3b932f92717/1556-276X-8-467-8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9916/4226245/b12608186f4f/1556-276X-8-467-9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9916/4226245/bb88a5e8065d/1556-276X-8-467-10.jpg

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2
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Pharmaceutics. 2013 May 15;5(2):294-317. doi: 10.3390/pharmaceutics5020294.
3
Molecular imaging for cancer diagnosis and surgery.用于癌症诊断和手术的分子成像
一种基于多孔还原氧化石墨烯/壳聚糖的纳米载体作为阿霉素的递送系统。
RSC Adv. 2019 Sep 27;9(53):30729-30735. doi: 10.1039/c9ra04977k. eCollection 2019 Sep 26.
4
Imaging-Guided Delivery of a Hydrophilic Drug to Eukaryotic Cells Based on Its Hydrophobic Ion Pairing with Poly(hexamethylene guanidine) in a Maleated Chitosan Carrier.基于疏水离子配对的马来化壳聚糖载体中聚六亚甲基胍对亲水性药物向真核细胞的成像引导递释。
Molecules. 2021 Dec 7;26(24):7426. doi: 10.3390/molecules26247426.
5
Enhanced sustained release of furosemide in long circulating chitosan-conjugated PLGA nanoparticles.速尿在长循环壳聚糖共轭聚乳酸-羟基乙酸共聚物纳米粒中的缓释增强
Res Pharm Sci. 2019 Mar 8;14(2):93-106. doi: 10.4103/1735-5362.253356. eCollection 2019 Apr.
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