Elmore E, Fitzgerald M P
NSI Technology Services Corporation, Research Triangle Park, NC 27709.
Prog Clin Biol Res. 1990;340D:379-87.
While present data suggest that the Mutatox assay is not effective for carcinogen screening, it does appear to detect many agents with diverse mechanisms of mutagenic activity with reasonable sensitivity as well as some known human teratogens. For general screening, more detailed studies need to be performed using coded agents with various mutagenic mechanisms as well as with toxicants of various classes including teratogens. With additional validation, the Mutatox assay, with its sensitivity to diverse chemical classes, may be valuable as a rapid, short-term, cost-effective assay.
虽然目前的数据表明Mutatox检测法对致癌物筛查无效，但它似乎确实能以合理的灵敏度检测出许多具有不同诱变活性机制的物质以及一些已知的人类致畸剂。对于一般筛查，需要使用具有各种诱变机制的编码试剂以及包括致畸剂在内的各类毒物进行更详细的研究。经过进一步验证，Mutatox检测法因其对不同化学类别物质的灵敏度，可能作为一种快速、短期、经济高效的检测法具有价值。
