Wang Xin-yue, Yan Xin
Gastroenterology Department, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, China.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2013 Mar;33(3):410-4.
Ulcerative colitis (UC), a kind of chronic nonspecific intestinal inflammation with unknown etiology, is very difficult to cure. It recurs often and even is accompanied with parenteral lesion. It has been rated as one of contemporary refractory diseases by World Health Organization. The author combines the pathological mechanisms of UC with the poison-evil theory and the collateral disease theory, and puts forward that "toxin impairing intestine collateral" pathogenesis theory. We believe that longer accumulation of damp-heat stasis toxin that damages the intestine collateral is the key cause for recurrence and relapses of UC. We explained its theory foundation in terms of pathogenesis of UC from Chinese medicine and modern medicine. The "toxin impairing intestine collateral" theory might perfect the syndrome typing system for UC, and provide a new way of thinking for treating UC.
溃疡性结肠炎（UC）是一种病因不明的慢性非特异性肠道炎症，极难治愈。它经常复发，甚至伴有肠外病变。它已被世界卫生组织列为当代难治性疾病之一。作者将UC的病理机制与毒邪理论和络病理论相结合，提出“毒损肠络”病机理论。我们认为，损伤肠络的湿热瘀毒长期蓄积是UC复发和病情反复的关键原因。我们从中医学和现代医学的角度，就UC的发病机制解释了其理论基础。“毒损肠络”理论可能会完善UC的辨证体系，并为治疗UC提供新的思路。
