Department of Nephrology, Hitit University Corum Education and Research Hospital, Corum, Turkey.
Ren Fail. 2013 Jul;35(6):891-5. doi: 10.3109/0886022X.2013.794682. Epub 2013 May 28.
It has been found out that the epicardial adipose tissue (EAT) measured by echocardiography is related with various metabolic parameters. Being accepted as the new cardiovascular risk indicator, there have been few studies on EAT in relation to the patients with end-stage renal failure. In our study, we aim to evaluate EAT and carotid intima media thickness (CIMT) in non-diabetic, non-hypertensive hemodialysis (HD) patients.
Our study recruited 47 non-diabetic, non-hypertensive HD patients (22 males, 25 females, median age 54 (44.3-60.8) years) and an age-gender matched control group consisting 41 healthy subjects (17 males, 24 females, median age 52 (48-56) years). In all patients, EAT was measured by echocardiography and CIMT by ultrasonography; and routine laboratory parameters were studied.
In our study, we obtained laboratory findings matching with the profiles of uremic patients among HD patients and CIMT values of HD patients are significantly higher than that of the control group [0.79 (0.64-0.93) vs. 0.6 (0.53-0.68) p < 0.001], and EAT values are similar [0.5 (0.33-0.6) vs. 0.4 (0.4-0.53) p > 0.05].
EAT is not a cardiovascular risk indicator in HD patients without diabetes mellitus and hypertension. Besides, echocardiographic measurement of EAT is easy, non-invasive, cheap and credible method.
通过超声心动图测量的心外膜脂肪组织（EAT）与各种代谢参数有关。作为新的心血管风险指标，目前关于终末期肾病患者 EAT 的研究较少。在本研究中，我们旨在评估非糖尿病、非高血压血液透析（HD）患者的 EAT 和颈动脉内膜中层厚度（CIMT）。
本研究纳入了 47 名非糖尿病、非高血压的 HD 患者（22 名男性，25 名女性，中位年龄 54（44.3-60.8）岁）和 41 名年龄和性别匹配的健康对照组（17 名男性，24 名女性，中位年龄 52（48-56）岁）。在所有患者中，通过超声心动图测量 EAT，通过超声测量 CIMT，并研究了常规实验室参数。
在本研究中，我们获得了与 HD 患者尿毒症特征相符的实验室检查结果，并且 HD 患者的 CIMT 值明显高于对照组[0.79（0.64-0.93）比 0.6（0.53-0.68），p<0.001]，而 EAT 值相似[0.5（0.33-0.6）比 0.4（0.4-0.53），p>0.05]。
在无糖尿病和高血压的 HD 患者中，EAT 不是心血管风险指标。此外，EAT 的超声心动图测量是一种简单、无创、廉价且可靠的方法。
