Laboratory of Virology, Microbiology Department, Hospital Universitario 12 de Octubre, Avda de Córdoba s/n, 28041, Madrid, Spain.
Biomedical Research Institute imas12, Hospital Universitario 12 de Octubre, Madrid, Spain.
Eur J Clin Microbiol Infect Dis. 2019 Oct;38(10):1969-1973. doi: 10.1007/s10096-019-03632-w. Epub 2019 Jul 12.
Automation of viral diagnosis has led to an increase of BK virus (BKV) viral load (VL) requests. The aim of this study was to assess the suitability of serum creatinine (SCr) for controlling the demand and to study the clinical characteristics of BKV infection. This is a retrospective study including patients with BKV VL request during April-July 2017. Clinical records and SCr were analyzed. Five hundred samples from 333 patients were included; 61.4% of samples were from males (55.5 ± 14.8 years), and all belonged to transplant recipients (86.4% renal). BKV VL was detectable in 40 samples (8.0%) from 23 patients (6.9%), who presented high SCr (100% vs. 90.9%, P = 0.038). Most of detectable VLs (62.5%) belonged to patients in their first year post-transplant. Six patients with detectable VL (26.1%) developed clinical manifestations, most of them (83.3%) had a first BKV VL greater than 10,000 copies/mL (P = 0.001). In conclusion, SCr would be useful to identify suitable specimens for BKV VL testing without missing cases.
病毒诊断的自动化导致 BK 病毒 (BKV) 病毒载量 (VL) 请求的增加。本研究旨在评估血清肌酐 (SCr) 控制需求的适用性，并研究 BKV 感染的临床特征。这是一项回顾性研究，纳入了 2017 年 4 月至 7 月期间请求进行 BKV VL 检测的患者。分析了临床记录和 SCr。共纳入了 333 名患者的 500 份样本；61.4%的样本来自男性（55.5±14.8 岁），均为移植受者（86.4%为肾移植）。23 名患者的 40 份样本（8.0%）中可检测到 BKV VL，他们的 SCr 较高（100%比 90.9%，P=0.038）。可检测到的 VL 中，62.5%（62.5%）来自移植后第一年的患者。6 名可检测到 VL 的患者（26.1%）出现了临床表现，其中大多数（83.3%）的首次 BKV VL 大于 10,000 拷贝/ml（P=0.001）。总之，SCr 可用于识别适合进行 BKV VL 检测的标本，而不会漏检病例。
