Mayer Erica L
From the Breast Oncology Center, Dana-Farber Cancer Institute, and Harvard Medical School, Boston, MA.
Am Soc Clin Oncol Educ Book. 2013:9-14. doi: 10.14694/EdBook_AM.2013.33.9.
Adjuvant chemotherapy continues to play an important role in breast cancer management. Exposure to chemotherapy can lead to a variety of early and late long-term toxicities, including ovarian failure (with resultant infertility and sexual dysfunction), bone loss, weight gain, neurotoxicity, neurocognitive changes, cardiac toxicity and secondary malignancy. Although chemotherapy effects may vary in medical severity, all effects have the potential to lead to a decrease in quality of life and a decrement on overall health status. Improved understanding of the etiology and management of chemotherapy-related toxicity may allow optimization of patient selection for treatment and ameliorate the concerns of patients who are considering embarking on a chemotherapy program. This article presents an overview of relevant early and late long-term toxicities, with a focus on recent advances and clinical management.
辅助化疗在乳腺癌治疗中继续发挥着重要作用。接受化疗会导致多种早期和晚期长期毒性反应，包括卵巢功能衰竭（导致不孕和性功能障碍）、骨质流失、体重增加、神经毒性、神经认知改变、心脏毒性和继发性恶性肿瘤。尽管化疗的影响在医学严重程度上可能有所不同，但所有这些影响都有可能导致生活质量下降和整体健康状况恶化。对化疗相关毒性的病因和管理有更深入的了解，可能有助于优化治疗的患者选择，并减轻正在考虑接受化疗方案的患者的担忧。本文概述了相关的早期和晚期长期毒性反应，重点介绍了最新进展和临床管理。
