San-Miguel Jesús F, Paiva Bruno, Gutiérrez Norma C
From the Hospital Universitario de Salamanca, Salamanca, Spain; IBSAL, IBMCC (USAL-CSIC), Salamanca, Spain.
Am Soc Clin Oncol Educ Book. 2013. doi: 10.1200/EdBook_AM.2013.33.e313.
This article reviews the most relevant techniques currently used for the evaluation of patients with multiple myeloma. Although bone marrow morphologic examination and electrophoretic analysis of the monoclonal paraprotein and conventional x-rays remain the "gold standard" techniques for fast, accurate, and cost-effective diagnosis, other assays such as molecular cytogenetics, immunophenotyping, MRI, and PET-CT may contribute to a better assessment of patients with myeloma. Here, we will discuss not only the contribution of each technique to differential diagnosis of monoclonal gammopathies, but also the value of each parameter for determining prognosis and for monitoring treatment efficacy. In addition, possible technical pitfalls inherent to each technique will be analyzed.
本文综述了目前用于评估多发性骨髓瘤患者的最相关技术。尽管骨髓形态学检查、单克隆副蛋白的电泳分析和传统X线检查仍是快速、准确且经济高效诊断的“金标准”技术，但其他检测方法，如分子细胞遗传学、免疫表型分析、MRI和PET-CT，可能有助于更好地评估骨髓瘤患者。在此，我们不仅将讨论每种技术对单克隆丙种球蛋白病鉴别诊断的贡献，还将讨论每个参数在确定预后和监测治疗疗效方面的价值。此外，还将分析每种技术固有的可能技术缺陷。
