Department of Biological Sciences-Physiology, Cell and Developmental Biology, University of Alberta, Edmonton, AB T6G 2R3, Canada.
Department of Anatomy, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur 56000, Malaysia.
Int J Mol Sci. 2020 Oct 13;21(20):7539. doi: 10.3390/ijms21207539.
Multiple myeloma (MM) is a cancerous bone disease characterized by malignant transformation of plasma cells in the bone marrow. MM is considered to be the second most common blood malignancy, with 20,000 new cases reported every year in the USA. Extensive research is currently enduring to validate diagnostic and therapeutic means to manage MM. microRNAs (miRNAs) were shown to be dysregulated in MM cases and to have a potential role in either progression or suppression of MM. Therefore, researchers investigated miRNAs levels in MM plasma cells and created tools to test their impact on tumor growth. In the present review, we discuss the most recently discovered miRNAs and their regulation in MM. Furthermore, we emphasized utilizing miRNAs as potential targets in the diagnosis, prognosis and treatment of MM, which can be useful for future clinical management.
多发性骨髓瘤（MM）是一种以骨髓中浆细胞恶性转化为特征的癌性骨病。MM 被认为是第二大常见的血液恶性肿瘤，在美国每年报告有 20000 例新病例。目前正在进行广泛的研究，以验证诊断和治疗 MM 的方法。microRNAs（miRNAs）在 MM 病例中被证明失调，并在 MM 的进展或抑制中具有潜在作用。因此，研究人员研究了 MM 浆细胞中的 miRNAs 水平，并创建了工具来检测它们对肿瘤生长的影响。在本综述中，我们讨论了最近发现的 miRNAs 及其在 MM 中的调控。此外，我们强调了利用 miRNAs 作为 MM 的潜在诊断、预后和治疗靶点的可能性，这对未来的临床管理可能是有用的。
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