长期非进展性精英控制者中 HIV-1 双重感染的流行率。
Prevalence of HIV-1 dual infection in long-term nonprogressor-elite controllers.
机构信息
*Servicio de Virología Molecular, Centro Nacional de Microbiología (CNM), Instituto de Salud Carlos III, Madrid, Spain; †Centro Sanitario Sandoval, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain; ‡Laboratory of Immunovirology, Biomedicine Institute of Seville, Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, Virgen del Rocío University Hospital, IBiS/CSIC/SAS/University of Seville, Seville, Spain; §Unidad de Inmunología Viral, Centro Nacional de Microbiología (CNM), Instituto de Salud Carlos III, Madrid, Spain; ‖Enfermedades Infecciosas, Hospital Carlos III, Comunidad Autónoma de Madrid, Madrid, Spain; ¶Centro de Biología Molecular Severo Ochoa, CSIC/Universidad Autónoma de Madrid, Madrid, Spain; and #IrsiCaixa Foundation, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain.
出版信息
J Acquir Immune Defic Syndr. 2013 Nov 1;64(3):225-31. doi: 10.1097/QAI.0b013e31829bdc85.
INTRODUCTION
Human immunodeficiency virus type 1 (HIV-1) dual infection (DI) in long-term nonprogressor-elite controller patients (LTNP-EC) has been described only in sporadic cases and then, consequences in disease progression are not clearly established. To fill-up this limited knowledge, we analyzed, for the first time, the prevalence, host genetic polymorphisms, and clinical consequences of HIV-1 DI in a group of LTNP-EC.
METHODS
For DI detection, nucleotide sequences in env gene from viruses from 20 LTNP-EC were analyzed by maximum likelihood. Epidemiological and clinical parameters and host factors of patients were also studied.
RESULTS
DI was detected in 4 (20%) of the 20 LTNP-EC, of which 3 maintained the elite controller status. CD4⁺ T-cell counts were not different between single and DI patients although higher CD8⁺ T-cell counts were observed in DI patients, and, consequently, the CD4⁺/CD8⁺ ratios were lower in LTNP-EC DI patients.
CONCLUSIONS
Prevalence of HIV-1 DIs in LTNP-EC is similar to other groups of HIV-1 patients; in addition, DI was not associated with loss of disease control in the patients. These DI LTNP-EC patients showed, in comparison with single infected patients, higher numbers of CD8⁺ T cells and lower CD4⁺/CD8⁺ ratios.
简介
人类免疫缺陷病毒 1 型（HIV-1）双重感染（DI）在长期非进展性精英控制者患者（LTNP-EC）中仅在散发病例中被描述，然后，疾病进展的后果尚不清楚。为了填补这方面知识的不足，我们首次分析了一组 LTNP-EC 中 HIV-1 DI 的流行率、宿主遗传多态性和临床后果。
方法
为了检测 DI，我们通过最大似然法分析了 20 名 LTNP-EC 中病毒的 env 基因核苷酸序列。还研究了患者的流行病学和临床参数以及宿主因素。
结果
在 20 名 LTNP-EC 中，有 4 名（20%）检测到 DI，其中 3 名仍保持精英控制者状态。DI 患者和单感染患者的 CD4+T 细胞计数没有差异，尽管 DI 患者的 CD8+T 细胞计数较高，因此，LTNP-EC DI 患者的 CD4+/CD8+比值较低。
结论
HIV-1 DI 在 LTNP-EC 中的流行率与其他 HIV-1 患者群体相似；此外，DI 与患者疾病控制的丧失无关。与单感染患者相比，这些 DI LTNP-EC 患者的 CD8+T 细胞数量更高，CD4+/CD8+比值更低。
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